1. Zi-Ling Yong, Yu-Ting Chen, Ching Chan*, and Guan-Chiun Lee*. (2024) Enzymatic Production of Trehalose and Trehalulose by Immobilized Thermostable Trehalose Synthase. Journal of Agricultural and Food Chemistry, 72(41):22745-22752.
  2. Li-Ci Ye, Sih-Yao Chow, San-Chi Chang, Chia-Hung Kuo, Yung-Lin Wang, Yong-Jun Wei, Guan-Chiun Lee, Shwu-Huey Liaw, Wen-Ming Chen*, and Sheng-Chia Chen*. (2024) Structural and Mutational Analyses of Trehalose Synthase from Deinococcus radiodurans Reveal the Interconversion of Maltose–Trehalose Mechanism. Journal of Agricultural and Food Chemistry, 72(33):18649-18657.
  3. Pin-Jung Chen, Chien-An Yao, Po-Chung Chien, Han-Jung Tsai, Yi-Ru Chen, Jen-Hua Chuang, Pei-Li Chou, Guan-Chiun Lee, Wenwei Lin, and Yenshou Lin*. (2024) Paeonol Derivative, 6'-Methyl Paeonol, Attenuates Aβ-Induced Pathophysiology in Cortical Neurons and in an Alzheimer's Disease Mice Model. ACS Chemical Neuroscience, 15(4):724-734.
  4. Jeng-Wei Lu, Chin-Kai Huang, Yen-Chen Chen, Guan-Chiun Lee*, Yi-Jung Ho*. (2023) Virucidal activity of trehalose 6‐monolaurate against dengue virus in vitro. Drug Development Research, 84(8):1699-1708.
  5. Chia-Min Yeh, Yun-Ya Sun, Ting-Yu Chen, Yu Hung, Guan-Chiun Lee, Wen-Chin Yang, and Yenshou Lin*. (2023) Early Life Exposure to C16-Ceramide Improves Learning and Short-Term Memory Behavior during Adulthood in Mice. ACS Chemical Neuroscience, 14(8):1369-1378.
  6. Chia-Tsui Yeh, Chia-Ying Lee, Yi-Jung Ho, Sin-An Chen, Liang-Yu Chen, Ping-Cheng Liu ,Yuan-Fan Chin, An-Yu Chen, Po-Shiuan Hsieh , Yi-Jen Hung, Cheng-Cheung Chen* , Yu-Chie Wang* and Guan-Chiun Lee* (2022) Immunoglobulin Y Specific for SARS-CoV-2 Spike Protein Subunits Effectively Neutralizes SARS-CoV-2 Infectivity and Ameliorates Disease Manifestations In Vivo. Biomedicines, 10(11): 2774.
  7. Chih-Hsin Lin, Yu-Shao Hsieh, Ying-Chieh Sun, Wun-Han Huang, Shu-Ling Chen, Zheng-Kui Weng, Te-Hsien Lin, Yih-Ru Wu, Kuo-Hsuan Chang, Hei-Jen Huang, Guan-Chiun Lee*, Hsiu Mei Hsieh-Li* and Guey-Jen Lee-Chen*. (2022) Virtual Screening and Testing of GSK-3 Inhibitors Using Human SH-SY5Y Cells Expressing Tau Folding Reporter and Mouse Hippocampal Primary Culture under Tau Cytotoxicity, Biomolecules & Therapeutics, 31(1):127-138.
  8. Lee YS, Lai DM, Huang HJ, Lee-Chen GJ, Chang CH, Hsieh-Li HM*, and Lee GC*. (2021) Prebiotic Lactulose Ameliorates the Cognitive Deficit in Alzheimer’s Disease Mouse Model through Macroautophagy and Chaperone-Mediated Autophagy Pathways, Journal of Agricultural and Food Chemistry, 69(8):2422-2437.
  9. Chung YH, Lin CW, Huang HY, Chen SL, Huang HJ, Sun YC, Lee GC, Lee-Chen GJ, Chang YC*, Hsieh-Li HM*. (2020) Targeting Inflammation, PHA-767491 Shows a Broad Spectrum in Protein Aggregation Diseases. Journal of Molecular Neuroscience, 70(7):1140-1152.
  10. Chiu, YJ, Hsieh YH, Lin TH, Lee GC, Hsieh-Li HM, Sun YC, Chen CM, Chang KH*, Lee-Chen GJ *. (2019) Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease. Neurochemistry International, 125, 175-186.
  11. Huang HJ, Chen SL, Huang HY, Sun YC, Lee GC, Lee-Chen GJ, Hsieh-Li HM*, Su MT*. (2018) Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice. Psychopharmacology, 236(2), 763-773.
  12. Kuo LC, Song YQ, Yao CA, Cheng I, Chien CT, Lee GC, Yang WC, Lin Yenshou*. (2018) Ginkgolide A prevents the Aβ-induced depolarization of cortical neurons, Journal of Agricultural and Food Chemistry, 67 (1), 81–89.
  13. Chang KH#, Lee GC#, Huang CC, Kuo HC, Chen CM, Hsiao YC, Hsu HC, Hsu KJ, Lin CH, Chang CW, Lee-Chen GJ*, Wu YR*. (2018) Genetic and functional characters of GRN p.T487I mutation in Taiwanese patients with atypical parkinsonian disorders. Parkinsonism and Related Disorders, 51(2018), 61-66.
  14. Hsu CJ, Hsu WC, Lee DJ, Liu AL, Chang CM, Shih HJ, Huang WH, Lee-Chen GJ, Hsieh-Li HM, Lee GC*, Sun YC*. (2017) Investigation of the Bindings of a Class of Inhibitors with GSK3β Kinase Using Thermodynamic Integration MD Simulation and Kinase Assay. Chemical Biology & Drug Design, 90(2), 272-281.
  15. Chow SY, Wang YL, Hsieh YC, Lee GC, Liaw SH*. (2017) The N253F mutant structure of trehalose synthase from Deinococcus radiodurans reveals an open active-site topology. Acta Crystallographica Section F-Structural Biology Communications, F73(Pt 11), 588-594.
  16. Chih-Yu Tseng, Ming-Ho Iunn, Guan-Chiun Lee*. (2017) Putative gene regulation involved in the biosynthesis of Nostoc punctiforme exopolysaccharides. BioFormosa, 49, 29-38.
  17. Lin CH, Wu YR, Yang JM, Chen WL, Chao CY, Chen IC, Lin TH, Wu YC, Hsu KC, Chen CM, Lee GC, Hsieh-Li HM, Lee CM, Lee-Chen GJ*. (2016) Novel Lactulose and Melibiose Targeting Autophagy to Reduce PolyQ Aggregation in Cell Models of Spinocerebellar Ataxia 3. CNS & Neurological Disorders-Drug Targets, 15(3), 351-359
  18. Kuan-Jung Chen, Sabrina Sabrina, Nermeen S El-Safory, Guan-Chiun Lee, Cheng-Kang Lee*. (2016) Constitutive expression of recombinant human hyaluronidase PH20 by Pichia pastoris. Journal of Bioscience and Bioengineering, 122(6), 673-678.
  19. Lin CH, Hsieh YS, Wu YR, Hsu CJ, Chen HC, Huang WH, Chang KH, Hsieh-Li HM, Su MT, Sun YC*, Lee GC*, Lee-Chen GJ*. (2016) Identifying GSK-3β kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays. European Journal of Pharmaceutical Sciences, 89, 11-19.
  20. Kuo TC, Shaw JF*, Lee GC*. (2015) Improvement in the secretory expression of recombinant Candida rugosa lipase in Pichia pastoris. Process Biochemistry, DOI: 10.1016/j.procbio.2015.09.013
  21. Chen ZZ, Wang CM, Lee GC, Hsu HC, Wu TL, Lin CW, Ma CK, Lee-Chen GJ, Huang HJ*, Hsieh-Li HM*. (2015) Trehalose Attenuates the Gait Ataxia and Gliosis of Spinocerebellar Ataxia Type 17 Mice. Neurochemical Research, 40(4), 800-810.
  22. Kuo TC, Shaw JF, Lee GC*. (2015) Conversion of crude Jatropha curcas seed oil into biodiesel using liquid recombinant Candida rugosa lipase isozymes, Bioresource Technology, 192, 54–59.
  23. 李冠群 (民104)。藍菌胞外多醣類之研究與應用。47(08)期，食品工業月刊(27-35頁)。新竹市:財團法人食品工業研究所。
  24. Lee GC, Lin CH, Tao YC, Yang JM, Hsu KC, Huang YJ, Huang SH, Kung PJ, Chen WL, Wang CM, Wu YR, Chen CM, Lin JY, Hsieh-Li HM*, Lee-Chen GJ*. (2015) The potential of lactulose and melibiose, two novel trehalase-indigestible and autophagy-inducing disaccharides, for polyQ-mediated neurodegenerative disease treatment. Neurotoxicology, 48, 120-130.
  25. Wang YL, Chow SY, Lin YT, Hsieh YC, Lee GC*, Liaw SH*. (2014) Structures of trehalose synthase from Deinococcus radiodurans reveal that a closed conformation is involved in catalysis of the intramolecular isomerization. Acta Crystallographica Section D: Biological Crystallography, 70 (Pt 12), 3144-3154.
  26. Yang ST, Chen HM, Lee LC, Huang SH, Lin CH, Lee GC, Lee CK*, Lee-Chen GJ*. (2013) Interaction Analysis Between Polyglutamine-expanded TATA Box Binding Protein (TBP) and High Mobility Group Box 1 (HMGB1). BioFormosa, 48, 17-26.
  27. Kuo TC, Chang JW, Lee CK, Lee GC*. (2013) Establishment of a Pichia pastoris System to Highly Express Recombinant Protein. BioFormosa, 47, 43-49.
  28. Lee LC, Chen CM, Wang HC, Hsieh HH, Chiu IS, Su MT, Hsieh-Li HM, Wu CH, Lee GC, Lee-Chen GJ*, Lin JY*. (2012). Role of the CCAAT-Binding Protein NFY in SCA17 Pathogenesis. PLoS ONE, 7(4), e35302.
  29. El-Safory NS, Lee GC, Lee CK* (2011) Characterization of hyaluronate lyase from Streptococcus pyogenes bacteriophage H4489A, Carbohydrate Polymers, 84(3), 1182-1191.
  30. Lee LC, Yen CC, Malmis CC, Chen LF, Chen JC, Lee GC*, Shaw JF* (2011) Characterization of codon-optimized recombinant Candida rugosa lipase 5 (LIP5). Journal of Agricultural and Food Chemistry, 59(19), 10693-10698.
  31. Chang SW, Li CF, Lee GC, Yeh T, Shaw JF* (2011) Engineering the Expression and Biochemical Characteristics of Recombinant Candida rugosa LIP2 lipase by Removing Additional N-terminal Peptide and Regional Codon Optimization. Journal of Agricultural and Food Chemistry, 59(12), 6710-6719.
  32. Lee GC, Chepyshko H, Chen HH, Chu CC, Chou YF, Akoh CC, Shaw JF* (2010) Genes and Biochemical Characterization of Three Novel Chlorophyllase Isozymes from Brassica oleracea. Journal of Agricultural and Food Chemistry, 58(15), 8651–8657.
  33. Yen CC, Malmis CC, Lee GC, Lee LC, Shaw JF* (2010) Site-Specific Saturation Mutagenesis on Residues 132 and 450 of Candida rugosa LIP2 Enhances Catalytic Efficiency and Alters Substrate Specificity in Various Chain-Length of Triglycerides and Esters. Journal of Agricultural and Food Chemistry, 58(20), 10899-10905.
  34. Chen CKM#, Lee GC#, Ko TP, Guo RT, Huang LM, Liu HJ, Ho YF, Shaw JF*, Wang AHJ* (2009) Structure of the Alkalohyperthermophilic Archaeoglobus fulgidus Lipase Contains a Unique C-Terminal Domain Essential for Long Chain Substrate Binding. Journal of Molecular Biology, 390(4), 672-685. (# authors contributed equally) (SCI)
  35. Chou HH, Chang SW, Lee GC, Chen, YS, Yeh T, Akoh CC, Shaw JF* (2009) Site-directed mutagenesis improves the thermostability of a recombinant Picrophilus torridus trehalose synthase and efficiency for the production of trehalose from sweet potato starch, Food Chemistry, 119(3), 1017-1022. (SCI)
  36. Lee LC, Chen CM, Chen FL, Lin PY, Hsiao YC, Wang PR, Su MT, Hsieh-Li HM, Hwang JC, Wu CH, Lee GC, Singh S, Lin Y, Hsieh SY, Lee-Chen GJ*, Lin JY* (2009) Altered expression of HSPA5, HSPA8 and PARK7 in spinocerebellar ataxia type 17 identified by 2-dimensional fluorescence difference in gel electrophoresis. Clinica Chimica Acta, 400(1-2), 56-62. (SCI)
  37. Akoh CC, Chang SW, Lee GC, Shaw JF* (2008) Biocatalysis for the Production of Industrial Products and Functional Foods from Agricultural Produce. Journal of Agricultural and Food Chemistry, 56(22), 10445-10451. (SCI)
  38. Hsu KH, Lee GC*, Shaw JF* (2008) Promoter Analysis and Differential Expression of the Candida rugosa Lipase Gene Family in Response to Culture Conditions. Journal of Agricultural and Food Chemistry, 56(6), 1992-1998. (SCI)
  39. Lee LC, Chen YT, Yen CC, Chiang TC, Tang SJ, Lee GC*, Shaw JF* (2007) Altering the Substrate Specificity of Candida rugosa LIP4 by Engineering the Substrate-Binding Sites. Journal of Agricultural and Food Chemistry, 55(13), 5103-5108. (SCI)
  40. Wang JH, Tsai MY, Chen JJ, Lee GC*, Shaw JF* (2007) Role of the C-terminal domain of Thermus thermophilus trehalose synthase in the thermophilicity, thermostability, and efficient production of trehalose. Journal of Agricultural and Food Chemistry, 55(9), 3435-3443. (SCI)
  41. Chen YT, Hsu LH, Huang IP, Tsai TC, Lee GC, Shaw JF* (2007) Gene cloning and characterization of a novel recombinant antifungal chitinase from papaya (Carica papaya). Journal of Agricultural and Food Chemistry, 55(3), 714-722. (SCI)
  42. Wang JH, Tsai MY, Lee GC, Shaw JF* (2007) Construction of a recombinant thermostable beta-amylase-trehalose synthase bifunctional enzyme for facilitating the conversion of starch to trehalose. Journal of Agricultural and Food Chemistry, 55(4), 1256-1263. (SCI)
  43. Lumor SE, Jones KC, Ashby R, Strahan GD, Kim BH, Lee GC, Shaw JF, Kays SE, Chang SW, Foglia TA, Akoh CC* (2007) Synthesis and Characterization of Canola Oil-Stearic Acid-Based Trans-Free Structured Lipids for Possible Margarine Application. Journal of Agricultural and Food Chemistry, 55(26), 10692-10702. (SCI)
  44. Akoh CC, Chang SW, Lee GC, Shaw JF* (2007) Enzymatic Approach to Biodiesel Production. Journal of Agricultural and Food Chemistry, 55(22), 8995-9005. (SCI)

  1. Huang Y.J., Chen, T.S., Lee, G.C. (2024) Nostoc commune polysaccharide extract enhances the stem cell functions for the treatment of skin aging. The 38th Joint Annual Conference of Biomedical Science, The Association of Anatomists of the Republic of China. Mar 23-24, 2024. Taipei, Taiwan. Poster PY 129.
  2. Yeh, C.T., Lee, C.Y., Chen, S.A., Chen, L.Y., Liu, P.C., Chin, Y.F., Chen, A.Y., Chen, C.C., Ho Y.J., Hung, Y.J., Lee, G.C., Wang, Y.C. and Hsieh, P.S. (2021) The application of IgY antibody in the detection and treatment of SARS-CoV-2 infection. 2021 Chinese-Taipei Society of Laboratory Animals Sciences Annual Meeting and Academic Symposium. 28-29 October, 2021. Taipei, Taiwan. Poster 4.
  3. Kuo, L.C., Lee, G.C. and Lin, Y.* (2018) Ginkgolide A inhibits the Abeta-induced depolarization in primary neurons. The 17th Meeting of Consortium for Globalization of Chinese Medicine (CGCM). 8-10 August, 2018. Kuching, Sarawak, Malaysia. Poster 186.
  4. Lee GC (2015, August 6) Cyanobacterial Exopolysaccharides: Related Researches and Potential Biotechnological Applications. Oral Presentation at 2015年固碳與產油微藻資源應用研討會, Food Industry Research and Development Institute, Hsinchu, Taiwan
  5. Kuo TC, Shaw JF, Lee GC*. (2015, June 26-27) Conversion of crude Jatropha curcas seed oil into biodiesel using liquid recombinant Candida rugosa lipase isozymes. Poster session presented at the 20th BEST Conference & International Symposium on Biotechnology and Bioengineering (2015生物技術及生化工程國際會議暨第20屆生化工程年會), National Taiwan University of Science and Technology, Taiwan
  6. Hsu CJ, Chung CM, Hsu WC, Liu AL, Lee GC*, Sun YC*. (2015, June 16-18) Searching for GSK-3β Kinase Inhibitors: Docking Computation, Molecular Dynamics Simulation, and Kinase Assay. Poster session presented at the 8th Conference of Asian Consortium on Computational Materials Science (ACCMS-8), National Taiwan University of Science and Technology (NTUST), Taipei, Taiwan
  7. Kuo TC, Lee GC*. (2014, May 23) PTVA and low temperature greatly enhance the secretory expression of Candida rugosa lipase2 in Pichia pastoris. Poster session presented at the Symposium on Frontiers in Biopharmaceuticals 2014, National Taiwan Normal University, Gong-Guan campus, Taipei, Taiwan.
  8. Hsieh YC, Wang YL, Lin YT, Lee GC*, Liaw SH*. (2013, December 7-10) Crystal structure of trehalose synthase from Deinococcus radiodurans reveals an active conformation. Poster session presented at the 12th Meeting of the Asian Crystallographic Association, ASCA130252, The Hong Kong University of Science and Technology, Hong Kong.
  9. Lee GC, Lin CH, Tseng HH, Hsieh HM, Lee-Chen GJ (2012, November 27-December 1) Trehalose and its analogs as Potential Drugs for Treating PolyQ-Mediated SCA. Poster session presented at the Neurodegeneration Conference 2012, Cancun, Mexico.
  10. Kuo HL, Lee GC (2012, March 15-16) A microbial model to screen novel molecules for SCA 17 treatment: Monitoring protein solubility by structural complementation of β-galactosidase. Poster session presented at the 4th International Symposium on Ataxia in Taiwan, Academia Sinica, Taipei, Taiwan.
  11. Chen CKM, Lee GC, Ko TP, Guo RT, Huang LM, Liu HJ, Ho YF, Shaw JF, Wang AHJ (2009, June 14-18) Structure of the Alkalohyperthermophilic Archaeoglobus fulgidus Lipase Contains a Unique C-Terminal Domain Essential for Long Chain Substrate Binding. Poster presented at the 12th SCBA (Society of Chinese Bioscientists in America) International Symposium, Academia Sinica, Taipei.
  12. Chang SW, Chou HH, Lee GC, Chen YS, Yeh T, Akoh CC, Shaw JF (2009, May 3-6) Site-directed mutagenesis improves the thermostability of a recombinant Picrophilus torridus trehalose synthase and efficiency for the production of trehalose from sweet potato starch. Presented in the 100th AOCS Annual Meeting & Expo., Orlando, USA.
  13. Chang SW, Lee GC, & Shaw JF (2007, May 13-16) Efficient Production of Active Recombinant Candida Rugosa LIP3 Lipase in Pichia Pastoris and Biochemical Characterization of the Purified Enzyme. Paper presented at the 98th AOCS Annual Meeting & Expo., Quebec City Convention Centre, Quebec City, QC, Canada
  14. Lee GC, & Shaw JF. (2006, December 6-8). Simultaneous Production of Bioethanol and Health Food from Agricultural Produce by Enzymatic Process and Transgenic Plant. Paper presented at the International Symposium of Biocatalysis and Bioenergy, Taichung, Taiwan.
  15. Srivastava A, Akoh CC, Chang SW, Lee GC, & Shaw JF. (2006, April 30-May 3) LIP1-Catalyzed Transesterification of Tripalmitin with Oleic Acid to Produce Structured Lipids. Poster session presented at the 97th AOCS Annual Meeting & Expo., America's Center, St. Louis, Missouri, USA

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重組痲瘋樹脂肪酶之表達、定性與應用 2016/08/01 2017/07/31 科技部(原國科會) MOST 105-2313-B-003-003- 主持人
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阿茲海默氏症的治療策略—從基因到行為--以阿茲海默氏症小鼠模式評估GSK3抑制劑之治療潛力—奠基於電腦輔助藥物設計及激酶生化檢測(2/2) 2014/08/01 2015/07/31 國科會 103-2321-B-003-003 協同/共同主持人
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以蛋白質工程技術提升海藻糖合成酶轉化效率 2013/08/01 2014/07/31 國科會 NSC 102-2313-B-003 -001 主持人
阿茲海默氏症的治療策略—從基因到行為--以阿茲海默氏症小鼠模式評估GSK3抑制劑之治療潛力—奠基於電腦輔助藥物設計及激酶生化檢測(1/2) 2013/08/01 2014/07/31 國科會 NSC 102-2321-B-003-004 協同/共同主持人
新媒體科普傳播實作計畫(1/2) 2012/10/01 2013/09/30 國科會 101-2515-S-002-012- 協同/共同主持人
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嗜熱嗜鹼性Archaeoglobus fulgidus脂肪酶之結構與功能 2011/08/01 2012/07/31 國科會 NSC 98-2311-B-003 -002 -MY3 主持人
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嗜熱嗜鹼性Archaeoglobus fulgidus脂肪酶之結構與功能 2010/08/01 2011/07/31 國科會 NSC 98-2311-B-003-002-MY3 主持人
神經退化性疾病：第十七型多麩醯胺小腦萎縮症致病機轉與藥物發展研究－第十七型脊髓小腦萎縮症：治療疾病之新穎分子的合成與篩檢 2009/08/01 2010/07/31 國科會 NSC 97-2311-B-003-006-MY3 主持人
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  1. 李冠群 (民104)。藍菌胞外多醣類之研究與應用。47(08)期，食品工業月刊(27-35頁)。新竹市:財團法人食品工業研究所。

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