1. Y.-C. Ku, Y.-J. Wang, M. N. Lee, and Y.-S. Wang*, “ Divergent Copper Radical Chemistry From an Engineered Distributed Metal Coordination Reservoir in Modular Spider Silk Proteins,” Journal of the Chinese Chemical Society (2026): 1–12, https://doi.org/10.1002/jccs.70250.
  2. Naradun N., Chueakwon P., Kamkaew A., Hsu K.Y., Lee M.N., Chansaenpak K., Wang Y.S.* & Lai R.I.*, “Ferritin Fused with miniSOG for In Vitro Photodynamic Therapy”, 2025, ACS Appl. Bio Mater. 8, 3909–3919
  3. Tsou J.C.†, Tsou C.J.†, Wang C.H.†, Ko A.L.A.†, Wang Y.H., Liang H.H., Sun J.C., Huang K.F., Ko T.P., Lin S.Y. & Wang Y.S.*, “Site-specific histidine aza-Michael addition in proteins enabled by a ferritin-based metalloenzyme”, 2024. J. Am. Chem. Soc. 146, 33309–33315. (Featured as the Supplementary Cover of the issue, News reported by Natural Science Library Service Project: Chemistry Division, January, 2025, and Research Highlights at National Synchrotron Radiation Research Center website, January, 2025.)
  4. Jiang H.K.†, Weng J.H.†, Wang Y.H.†, Tsou J.C., Chen P.J., Ko A.L.A., Söll D., Tsai M.D. & Wang Y.S.*, “Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids”, 2023 Front. Genet. 14:1277489.
  5. Jiang H.K., Ambrose N., Chung C., Wang Y.S., Söll D.* & Tharp J.M.*, “Split aminoacyl-tRNA synthetases for proximity-induced stop codon suppression”, 2023 Proc. Natl. Acad. Sci. U.S.A. 120, e2219758120.
  6. Guo L.T.†, Amikura K.†, Jiang H.K.†, Mukai, T., Fu X., Wang Y.S., O’Donoghue P., Söll D.* & Tharp J.M.*, “Ancestral archaea expanded the genetic code with pyrrolysine”, 2022 J. Biol. Chem. 298:102521.
  7. Wang D., Kao M.R., Li J., Sun P., Meng Q., Vyas A., Liang P. H., Wang Y.S. & Hsieh Y.S.Y.*, “Novel two-step process in cellulose depolymerization: hematite-mediated photocatalysis by lytic polysaccharide monooxygenase and fenton reaction”, 2022 J. Agric. Food Chem. 70, 9941–9947.
  8. Jiang H.K., Lee M.N., Tsou C.J., Chang K.W. Tseng H.W., Chen K.P., Li Y.K. & Wang Y.S.*, “Linker and N-terminal domain engineering of pyrrolysyl-tRNA synthetase for substrate range shifting and activity enhancement”, 2020 Front. Bioeng. Biotechnol. 8:235.
  9. Jiang H.K.†, Wang Y.H.†, Weng J.H.†, Lee M.N., Li C.L., Kurkute P., Chen P.J., Tseng H.W., Tsai M.D. & Wang Y.S.*, “Probing the active site of deubiquitinase USP30 with non-canonical tryptophan analogues”, 2020 Biochemistry 59, 2205–2209. (Selected as the Supplementary Cover of the issue, and mentioned in ACS Axial as the most read article in June 2020 in Biochemistry.)
  10. Tseng H.W., Baumann T., Sun H., Wang Y.S., Ignatova Z. & Budisa N.*, “Expanding the scope of orthogonal translation with pyrrolysyl-tRNA synthetase dedicated to aromatic amino acids”, 2020 Molecules 25, 4418.
  11. Wang Y.S.*, Wu K.P.*, Kurkute P., Jiang H.K. & Chen R.H.* “Branched ubiquitination: detection methods, biological functions and chemical synthesis”, 2020 Molecules 25, 5200.

名稱 開始日期 結束日期 委託單位 編號 參與身份別
新穎蛋白麥克連接酶設計優化與抗登革熱病毒抗體定點修飾研究(1/3) (The Novel Michael Ligase Design and Its Application for Site-specific Chemical Modifications of Dengue Virus Neutralizing Antibody 2/3) 2026/08/01 2027/07/31 國科會 115-2113-M-003 -015 主持人
前瞻藍色生物冶金技術開發計畫：以工程化蛋白質將海洋戰略資源與汙染物轉化為高熵半導體材料 (Advanced Blue Bio-metallurgy Development Project: Converting Marine Strategic Resources and Pollutants into High-Entropy Semiconductor Materials using Engineered Proteins) 2026/04/01 2026/11/30 其他政府部門 SCI1150056 總主持人
探索人工設計麥克加成酵素透過 SuTEx 分子圖書館展現的蛋白側鏈殘基及位置選擇性 2026/02/01 2026/08/31 其他 主持人
新穎蛋白麥克連接酶設計優化與抗登革熱病毒抗體定點修飾研究(1/3) (The Novel Michael Ligase Design and Its Application for Site-specific Chemical Modifications of Dengue Virus Neutralizing Antibody 1/3) 2025/08/01 2026/07/31 國科會 NSTC 114-2113-M-003-019 主持人
含非典型胺基酸蛋白做為探測蛋白交互作用及聚泛素拓樸學(2/2) (Genetically encoded non-canonical amino acid for probing protein-protein interactions and polyubiquitin topology 2/2) 2024/08/01 2025/07/31 國科會 NSTC 113-2113-M-001-006 主持人
含非典型胺基酸蛋白做為探測蛋白交互作用及聚泛素拓樸學(1/2) (Genetically encoded non-canonical amino acid for probing protein-protein interactions and polyubiquitin topology 1/2) 2023/08/01 2024/07/31 國科會 NSTC 112-2113-M-001-015 主持人
含非典型胺基酸嵌入蛋白設計及藥物鍵結複合蛋白應用 (Protein design using genetic code expansion and protein-drug conjugates applications) 2022/08/01 2023/07/31 國科會 MOST 111-2113-M-001-039 主持人
體內D型非典型胺基酸嵌入平台建立及篩選混合鏡像胜肽及蛋白藥物應用 (Genetically encoded D-noncanonical amino acids development and their design in heterochiral peptide and protein therapeutics) 2021/08/01 2922/07/31 國科會 MOST 110-2113-M-001-044 主持人
體內非典型胺基酸嵌入酵素功能性探究及新穎功能蛋白設計應用 (Enzyme Functional Manipulation with Genetically Encoded Noncanonical Amino Acids and Novel Functional Protein Design) 2018/08/01 2021/07/31 國科會 MOST 107-2113-M-001-025-MY3 主持人

  1. Hsu, KY., Wang, YS*. Synthesizing Defined Ubiquitin-Modified SUMO Dimers. 2025, In: Lecona, E., Rivas, C. (eds) SUMO. Methods in Molecular Biology, vol 2957. p83-97, Humana, New York, NY. https://doi.org/10.1007/978-1-0716-4710-3_6