1. Chen, T.Y., Chen, Y.R., Hsu, M.L., Liao, Y.T., Wu, C.H., Yao, C.A., Yang W.C., Lin, W.* and Lin, Y.* (2024) Homoplantaginin antagonizes NMDAR and ERK signaling in Aβ oligomers-induced neuropathology/toxicity. J Agric Food Chem 72: 28294-28304
  2. Chen, P.J.#, Yao, C.A.#, Chien, P.C., Tsai, H.J., Chen, Y.R., Chuang, J.H., Chou, P.L., Lee, G.C., Lin, W. and Lin, Y.* (2024) A paeonol derivative, 6’-methyl paeonol, attenuates Aβ-induced pathophysiology in cortical neurons and in an Alzheimer’s disease mice model. ACS Chem Neurosci 15: 724-734 (#: contributed equally)
  3. Yeh, C.M., Sun, Y.Y., Chen, T.Y., Hung, Y., Lee, G.C., Yang, W.C. and Lin, Y.* (2023) Early life exposure to C16-ceramide improves learning and short-term memory behavior during adulthood in mice. ACS Chem Neurosci 14: 1369-1378
  4. Chuang, J.-H., Yang, W.-C. and Lin, Y.* (2021) Glutamatergic neurons differentiated from embryonic stem cells: an investigation of differentiation and associated diseases. Int J Mol Sci 22: 4592
  5. Apaya, M.K. Kuo, T.F., Yang, M.T., Yang, G., Hsiao C.L., Chang, S.B., Lin, Y. and Yang, W.C.* (2020) Phytochemicals as modulators of β-cells and immunity for the therapy of type 1 diabetes: Recent discoveries in pharmacological mechanisms and clinical potential. Pharmacol Res 156: 104754
  6. Kuo, L.C., Song, Y.Q., Yao, C.A., Cheng, I., Chien, C.T., Lee, G.C., Yang, W.C., and Lin, Y.* (2019) Ginkgolide A prevents the Aβ-induced depolarization of cortical neurons. J Agric Food Chem 67: 81-89
  7. Chen, W.Y.#, Lin, C.L.#, Chuang, J.H., Chiu, F.Y., Sun, Y.Y., Liang, M.C. and Lin, Y.* (2017) Heterogeneous nuclear ribonucleoprotein M associates with mTORC2 and regulates muscle differentiation. Sci Rep 7: 41159 ( #: contributed equally)
  8. Yao, C.A., Ortiz-Vega, S., Sun, Y.Y., Chien, C.T. Chuang, J.H. and Lin, Y.* (2017) Association of mSin1 with mTORC2 Ras and Akt reveals a crucial domain on mSin1 involved in Akt phosphorylation. Oncotarget 8: 63392-63404
  9. Lin, T.S.#, Tsai, H.J.#, Lee, C.H., Song, Y.Q., Huang, R.S., Hsieh-Li, H.M., Liang, M.C. and Lin, Y.* (2017) An improved drugs screening system reveals that baicalein ameliorates the Aβ/AMPA/NMDA-induced depolarization of neurons. J Alzheimers Dis 56: 959-976 (#: contributed equally)
  10. Chen C.Y., Chiu, F.Y., Lin, Y., Huang, W. J., Hsieh, P.S., Hsu, F. L.* (2015) Chemical constituents analysis and antidiabetic activity validation of four fern species from Taiwan. Int J. Mol Sci. 16: 2497-2516
  11. Chuang, J.H., Tung, L. C., Lin, Y.* (2015) Neural differentiation from embryonic stem cells in vitro: An overview of the signaling pathways. World J. of Stem Cells 7:437-447
  12. Hsieh, C.T.#, Chuang, J.H.#, Yang W.C., Yin, Y. and Lin, Y.* (2014) Ceramide inhibits insulin-stimulated Akt phosphorylation through activation of Rheb/mTORC1/S6K signaling in skeletal muscle. Cell Signal 26: 1400-1408 (#: contributed equally)
  13. Chuang, J. H., Tung, L. C., Yin, Y., and Lin, Y.* (2013) Differentiation of glutamatergic neurons from mouse embryonic stem cells requires raptor S6K signaling. Stem Cell Res 11:1117-1128
  14. Chang, C. L. T., Lin, Y., Bartolome, A. P., Chen, Y. C., Chiu, S. C. and Yang W. C. (2013) Herbal therapies for type 2 diabetes mellitus: chemistry, biology, and potential application of selected plants and compounds. Evid.-based Complement Altern. Med. 2013: Article ID 378657, 33 pages
  15. Chuang, J. H., Tung, L. C., Lee-Chen, G. J., Yin, Y., and Lin, Y.* (2011) An approach for differentiating uniform glutamatergic neurons from mouse embryonic stem cells. Anal. Biochem. 410: 149-151
  16. Chuang, J.H., Kao, Y.J., Ruderman, N.B., Tung, L.C. and Lin, Y.* (2011) Optimal concentrations of MEGA-10 and SDS allow the extraction and analysis of membrane proteins Anal. Biochem. 418: 298-300
  17. Lin, Y.* and Avruch, J. (2009) pTOM, a vector for expressing two proteins in mammalian cells. Anal. Biochem. 388: 353-355
  18. Lee, L.C., Chen, C.M., Chen, F.L., Lin, P.Y., Hsiao, Y.C., Wang, P.R., Su, M.T., Hsieh-Li, H.M., Hwang, J.C., Wu, C.H., Lee, G.C., Singh, S., Lin, Y., Hsieh, S.Y., Lee-Chen, G.J. and Lin, J.Y.* (2009) Altered expression of HSPA5, HSPA8 and PARK7 in spinocerebellar ataxia type 17 identified by 2-dimensional fluorescence difference in gel electrophoresis. Clin Chim Acta, 400: 56-62
  19. Avruch, J.*, Long, X., Lin, Y., Ortiz-Vega, S., Rapley, J., Papageorgiou, A., Oshiro, N., Kikkawa, U. (2009) Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor. Biochem Soc Trans. 37: 223-226
  20. Hagan, G.N., Lin, Y., Magnuson, M.A., Avruch, J. and Czech, M.P.* (2008) A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes. Mol Cell Biol. 28: 4215-4226
  21. Long, X., Lin, Y., Ortiz-Vega, S., Busch, S. and Avruch, J.* (2007) The Rheb switch 2 segment is critical for signaling to Target of Rapamycin complex 1. J. Biol. Chem. 282: 18542-18551
  22. Avruch, J.*, Hara, K., Lin, Y., Liu, M., Long, X., Ortiz-Vega, S. and Yonezawa, K. (2006) Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase. Oncogene 25: 6361-6372
  23. Long, X., Ortiz-Vega, S., Lin, Y. and Avruch, J.* (2005) Rheb binding to mTOR is regulated by amino acid sufficiency. J. Biol. Chem. 280: 23433-23436
  24. Avruch, J.*, Lin Y., Long X., Murthy S. and Ortiz-Vega S. (2005) Recent advances in the regulation of the TOR pathway by insulin and nutrients. Curr Opin Clin Nutr Metab Care. 8: 67-72
  25. Long, X. #, Lin, Y. #, Ortiz-Vega, S., Yonezawa K., and Avruch, J.* (2005) Rheb binds and regulates the mTOR kinase. Curr. Biol. 15: 702-713 (#: Contributed equally)
  26. Lin, Y., Brady, M.J., Wolanske, K., Holbert, R., Ruderman, N.B.* and Yaney, G.C. (2002) Alterations of nPKC distribution, but normal Akt/PKB activation in denervated rat soleus muscle. Am J Physiol Endocrinol Metab 283: E318-325
  27. Lin, Y., Khokhlatchev, A., Figeys, D. and Avruch, J.* (2002) Death associated protein 4 binds MST1 and augments MST1-induced apoptosis. J. Biol. Chem. 277: 47991-48001
  28. Tomas, E., Lin, Y., Dagher, Z., Saha, A., Luo, Z., Ido, Y. and Ruderman, N. B.* (2002) Hyperglycemia and insulin resistance possible mechanisms. Ann. N. Y. Acad. Sci. 967: 43-51
  29. Lin, Y., Itani, S. I., Kurowski, T.G., Dean, D. J., Luo, Z., Yaney, G.C. and Ruderman, N.B.* (2001) Inhibition of insulin signaling and glycogen synthesis by phorbol dibutyrate in rat skeletal muscle. Am J Physiol Endocrinol Metab 281: E8-15
  30. Kurowski, T.G. Lin, Y., Luo, Z., Tsichlis, P.N., Buse, M.G., Heydrick, S.J. and Ruderman, N.B.* (1999) Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle. Diabetes 48: 658-663

  1. Liao, Y. T. and Lin, Y.* (2024) The effect of rutin on calcium influx and signaling pathway in cortical glutamatergic neurons. The 38th Joint Annual Conference of Biomedical Sciences. 23-24 March, 2024. Taipei, Taiwan. Poster CM008
  2. Hsu, M. L. and Lin, Y.* (2024) The effect of an herbal extract on Aβ oligomers-induced calcium influx in cortical glutamatergic neurons. The 38th Joint Annual Conference of Biomedical Sciences. 23-24 March, 2024. Taipei, Taiwan. Poster CM024
  3. Wu, C. H. and Lin, Y.* (2023) A baicalein derivative inhibits Aβ-induced depolarization and NMDA-induced calcium influx in cortical glutamatergic neurons. The 37th Joint Annual Conference of Biomedical Sciences. 18-19 March, 2023. Taipei, Taiwan. Poster CM145
  4. Chen, P. J. and Lin, Y.* (2022) A herbal extract derivative alleviates A𝛽 oligomers-induced abnormal depolarization in primary neurons. The 36th Joint Annual Conference of Biomedical Sciences. 26-27 March, 2022. Taipei, Taiwan. Poster CM113
  5. Chen, T. Y. and Lin, Y.* (2022) A baicalein derivative ameliorates AMPA/NMDA-induced depolarization in primary cortical neurons. The 36th Joint Annual Conference of Biomedical Sciences. 26-27 March, 2022. Taipei, Taiwan. Poster CM112
  6. Yeh, C. M., Sun, Y.Y. and Lin, Y.* (2021) Effect of ceramides exposure after wean on the learning behavior of adult mice. The 35th Joint Annual Conference of Biomedical Sciences. 15-16 May, 2021. Taipei, Taiwan. Poster CM153 (the meeting was canceled)
  7. Lin, Y.*, Kuo, L-C, and Chuang, J. H. (2020) The herbal medicine extract rutin reduces beta amyloid-induced depolarization of glutamatergic neurons. Experimental Biology 2020, 4-7 April, 2020, San Diego, U.S.A. (the meeting was canceled) FASEB J. 34, 1_supplement
  8. Su, Y. R. and Lin, Y.* (2019) Using neurons differentiated from mouse embryonic stem cells as a drug screening model. The 34th Joint Annual Conference of Biomedical Sciences. 23-24 March, 2019. Taipei, Taiwan. Poster CM071
  9. Yeh, C. M., Sun, Y.Y. and Lin, Y.* (2019) Early exposure of ceramides during neonatal stage affects memorial behavior. The 34th Joint Annual Conference of Biomedical Sciences. 23-24 March, 2019. Taipei, Taiwan. Poster CM072
  10. 1. Kuo, L.C., Lee, G.C. and Lin, Y.* (2018) Ginkgolide A inhibits the Abeta-induced depolarization in primary neurons. The 17th Meeting of Consortium for Globalization of Chinese Medicine (CGCM). 8-10 August, 2018. Kuching, Sarawak, Malaysia. Poster 186
  11. Sun, Y.Y. and Lin, Y.* (2018) Effect of ceramides at early lives exposure on behavior/memory of adult mice. The 33th Joint Annual Conference of Biomedical Sciences. 24-25 March, 2018. Taipei, Taiwan. Poster CM129
  12. Huang, R.S. and Lin, Y.* (2018) Ceramides antagonize glutamate-induced glucose uptake on primary neurons. The 33th Joint Annual Conference of Biomedical Sciences. 24-25 March, 2018. Taipei, Taiwan. Poster CM031
  13. Sun, Y.Y. and Lin, Y.* (2017) Effect of hnRNP M on mTOR kinase activity and metastasis of cancer cells. The 32th Joint Annual Conference of Biomedical Sciences. 25-26 March, 2017. Taipei, Taiwan. Poster CM170
  14. Song, Y.Q. and Lin, Y.* (2017) The effect of pure compound AG on primary culture neurons and a transgenic mouse model of Alzheimer’s disease. The 32th Joint Annual Conference of Biomedical Sciences. 25-26 March, 2017. Taipei, Taiwan. Poster CM171
  15. Kuo, L.C., Lee, C. H., Tsai, H. J., Lin T. and Lin, Y.* (2016) Pure compounds TR and AG from Chinese herbal medicines mediate glutamate receptors to attenuate Aβ-induced neuronal pathophysiology. The 31th Joint Annual Conference of Biomedical Sciences. 26-27 March, 2016. Taipei, Taiwan. Poster P622
  16. Lin, Y. (2015) Herbal medicines for ameliorating the Aβ-induced depolarization in primary cortical neurons. The East Asia Joint Symposium (EAJS) 10-15 Nov, 2015, Okinawa, Japan. Oral Presentation
  17. Lin, T.S., Lee, C. H., Tsai, H. J. and Lin, Y.* (2015) Nature compounds for ameliorating Aβ-induced neuronal pathophysiology. The Joint 2015 Forum of Biotechnology, Medicine, Ecology and Evolution and the 12th Symposium of the Frontiers of Biomedical Sciences. 29-30 May, 2015. Taipei, Taiwan. Poster MS17
  18. Lin, T. S. and Lin, Y.* (2015) Pure compounds screened from herbal extracts are capable to alleviate Aβ-induced neuronal pathophysiology. The 30th Joint Annual Conference of Biomedical Sciences. 21-22 March, 2015. Taipei, Taiwan. Poster P327
  19. Lee, C. H., Tsai, H. J. and Lin, Y.* (2014) Herbal medicines for ameliorating Aβ-induced neurotransmission of glutamate. Drug Discovery & Therapy World Congress 2014, 16-19 June, 2014, Boston, USA. Oral SL-20
  20. Tsai, H. J. and Lin, Y.* (2014) Screening of Chinese herbal medicine for reducing Aβ-induced neurotoxicity through glutamate neurotransmission. Biopharmaceutical Frontiers 2014 National Taiwan Normal University. 23 May, 2014. Taipei, Taiwan. Poster A03
  21. Chen, W. Y. and Lin, Y.* (2014) The role of rictor/RICAP in morphological regulation of primary cortical neurons. Biopharmaceutical Frontiers 2014 National Taiwan Normal University. 23 May, 2014. Taipei, Taiwan. Poster A02
  22. Lee, C. H. and Lin, Y.* (2014) To screen Chinese herbal medicines for ameliorating Aβ-induced pathophysiological neurotransmission of glutamate. Biopharmaceutical Frontiers 2014 National Taiwan Normal University. 23 May, 2014. Taipei, Taiwan. Poster A12
  23. Tsai, H.J. and Lin, Y (2014) To screen Chinese herbal medicines for ameliorating Aβ-induced neurotransmission of glutamate. The 29th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. P437
  24. Chen, W.Y. and Lin, Y (2014) The role of RICAP/mTORC2 in neuronal growth and morphology. The 29th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan. P390
  25. Lin, C.L. and Lin, Y.* (2013) Muscle differentiation requires RICAP, a novel component in mTOR complex 2. The 28th Joint Annual Conference of Biomedical Sciences. 23-24 March, 2013. Taipei, Taiwan. Poster 342
  26. Lee, C.H. and Lin, Y.* (2013) Adiponectin/PPARbeta signaling pathway – PPARbeta associated protein(s). The 28th Joint Annual Conference of Biomedical Sciences. 23-24 March, 2013. Taipei, Taiwan. Poster 141
  27. Hsieh, C. T., Chuang, J. H. and Lin, Y.* (2013) Ceramide decreases insulin signaling through activating mTORC1 pathway. The 28th Joint Annual Conference of Biomedical Sciences. 23-24 March, 2013. Taipei, Taiwan. Poster 403
  28. Lin, C.L. and Lin, Y.* (2012) A novel associated protein of rictor and its role in muscle myogenesis. The Cross Strait 2012 Life Science and Technology Symposia. 4-5 October, 2012. Taipei, Taiwan. Poster M003
  29. Lee, C.H. and Lin, Y.* (2012) Signal transduction of adiponectin –signaling pathway involving PPARs and possible associated protein(s). The Cross Strait 2012 Life Science and Technology Symposia. 4-5 October, 2012. Taipei, Taiwan. Poster M002
  30. Chuang, J. H., Chiu, F.Y., and Lin, Y.* (2012) A novel rictor associated protein RICAP is essential for neurites survival. The 27th Joint Annual Conference of Biomedical Sciences. 17-18 March, 2012. Taipei, Taiwan. Poster 263
  31. Chiu, F.Y., Hsu, F. L., Lin, Y. and Hsieh P.S. (2012) A protective effect of Nstpbp168, a novel AMPK activator on H2O2-induced cell damage and ROS production in insulin secreting cell line. The 27th Joint Annual Conference of Biomedical Sciences. 17-18 March, 2012. Taipei, Taiwan. Poster 894
  32. Chuang, J. H., Tung, L. C., and Lin, Y.* (2011) mTOR complex 1 is essential for growth and differentiation of neurons derived from mouse embryonic stem cells. Experimental Biology 2011, 9-13 April, 2011, Washington DC, U.S.A. Poster D272. FASEB J. 2011; 25: 829.2
  33. Chuang, J. H., Tung, L. C., and Lin, Y.* (2011) Growth and differentiation of neurons derived from embryonic stem cells require mTOR complex 1. The 26th Joint Annual Conference of Biomedical Sciences. 19-20 March, 2011. Taipei, Taiwan. Oral77
  34. Hsieh, C. T. and Lin, Y.* (2011) Mechanisms of decreased insulin signalings by ceramide in skeletal muscle cells. The 26th Joint Annual Conference of Biomedical Sciences. 19-20 March, 2011. Taipei, Taiwan. Poster 156
  35. Chiu, B. C. and Lin, Y.* (2011) Binding partners in adiponectin signaling pathway using yeast two hybrid and immunoprecipitation approaches. The 26th Joint Annual Conference of Biomedical Sciences. 19-20 March, 2011. Taipei, Taiwan. Poster 157
  36. Lin, Y.* (2008) Regulation of mTOR complex 1 by a small GTPase Rheb. The 5th Life Science and Technology Symposia. Oct 2-4, 2008. Taipei, Taiwan. Oral p31 (Invited speaker)
  37. Long, X., Lin, Y., Ortiz-Vega, S, Yonezawa K., and Avruch, J.* (2004) Insulin and nutrient regulation of the TOR pathway. Milan, Italy
  38. Dean, D.J., Kaushik, V. K., Lin, Y., Kurowski, T.G. and Ruderman, N.B.* (2000) Stimulation of muscle glucose transport by 5-Aminoimidazole-4-Carboxamide 1--D-Ribofuranoside (AICAR) varies with fiber type. American Diabetes Association. 9-13 June, 2000. San Antonio, Texas, U.S.A. Diabetes. 49 (supply 1) A193
  39. Lin, Y., Yaney, G.C. and Ruderman, N.B.* (1999) Altered protein kinase C distribution, But normal Akt/PKB activation in insulin resistant denervated muscle. American Diabetes Association. 19-22 June, 1999. San Diego, California, U.S.A. Diabetes. 48 (supply 1) A64 (President poster)
  40. Lin, Y. Ruderman, N.B.* and Yaney, G.C. (1998) Assessment of protein kinase C distribution in insulin resistant rat muscles. Evans/Medical Research. 18-20 November, 1998. Boston. MA, U.S.A.
  41. Chien, E.J., Lin, Y., Chen, J., Wang, P.S. and Lin, C. (1995) Phytohemagglutinin-induced changes in membrane phospholipid-N-methylation and calcium influx in human mononuclear cells. American Society for Biochemistry and Molecular Biology. 21-25 May, 1995. San Francisco, CA, U.S.A. FASEB J. 9(6) A1382
  42. Chien, E. J.*, Lin, T-S., Chien, C-H., Lin, Y-S., Lai,Y-L., Wang, P.S. and Lin, C-Y. (1994) Inhibition of phytohemagglutinin-induced calcium entry by staurosporine in human T lymphocytes. American Society for Biochemistry and Molecular Biology. 20-25 May, 1994. Washington, DC, U.S.A. FASEB J. 8(7) A1458
  43. Lai Y. L., Lin Y. S. and Chien E. J.* (1992) Relationship between phospholipid-N-methylation and calcium signal in human monocytes stimulated by phytohemagglutinin (PHA) and thymic extract (Thymostimulin, TP-1). The Seventh Joint Annual Conference of Biomedical Sciences. April, 1992. Taipei.
  44. Wang, T. L., Hwang, C. Y., Yu, J. C., Lin, Y.S., Yeh, M. H., Chiang, S. T. and Wang, P.S.* (1990) Age-related differences in urinary excretion of sodium and plasma concentration of atrial natriuretic factor and vasopressin in male rats. The Fifth Joint Annual Conference of Biomedical Sciences. April, 1990. Taipei.

  1. Lin Y., Yang MT., Tran Nguyen Minh H., Yang WC.* (2019) Polyynes in Food. In: Xiao J., Sarker S., Asakawa Y. (Eds) Springer Publishing. Handbook of Dietary Phytochemicals 1-36.
  2. Lin, Y.* (2012) Differentiation of embryonic stem cells into glutamatergic neurons (methods). In: M.A. Hayat (Ed), Springer Science Publishing. Stem cells and cancer stem cells: Therapeutic applications in disease and injury. 6: 47-55 (Invited book chapter)
  3. Avruch, J.*, Long, X., Lin, Y., Ortiz-Vega, S., Rapley, J. and Oshiro, N. (2010) Regulation of TOR complex 1 by amino acids through small GTPase. In: M. Hall and F. Tamanoi (Ed), Structure, function and regulation of TOR complexes from Yeasts to mammals. Elsevier Inc Academic Press. The Enzymes. 27: 57-73