1. Chen, S. J., Wu, C. L., Lin, L. Y., & Horng, J. L. (2025). Evaluating N-acetylcysteine for mitigating cisplatin-induced oxidative stress and ionocyte damage in a zebrafish model. Toxicology and Applied Pharmacology, 117401.
  2. Lin, L. Y., Yeh, F. H., Lee, K. Y., & Horng, J. L. (2025). Pyraclostrobin disrupts ion regulation by suppressing mitochondrion-rich ionocyte differentiation in zebrafish embryos. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 110289.
  3. Chua, F. Z., Lin, L. Y., Tseng, Y. C., & Chou, M. Y. (2025). A sexual dimorphism in zebrafish aggression and metabolism under acute ammonia stress. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 110131.
  4. Horng, J. L., Lee, K. Y., & Lin, L. Y. (2025). Sublethal effects of acidified water on sensorimotor responses and the transcriptome of zebrafish embryos. Chemosphere, 370, 143984.
  5. Horng, J. L., Lee, K. Y., Wu, J. L., & Lin, L. Y. (2025). Assessing the toxicity of bongkrekic acid in zebrafish embryos. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 110235.
  6. Horng, J. L., Hsiao, B. Y., Lin, W. T., Lin, T. T., Chang, C. Y., & Lin, L. Y. (2024). Investigation of verapamil-induced cardiorenal dysfunction and compensatory ion regulation in zebrafish embryos. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 109980.
  7. BY Hsiao, JL Horng, CH Yu, WT Lin, YH Wang, LY Lin,2024,Assessing cardiovascular toxicity in zebrafish embryos exposed to copper nanoparticles, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology,109838.
  8. Horng, J. L., Kung, G. X., & Lin, L. Y. (2024). Acidified water promotes silver-induced toxicity in zebrafish embryos. Aquatic Toxicology, 106865.
  9. Lin, L. Y., Cheng, C. A., Liu, S. T., & Horng, J. L. (2024). Investigation of ammonia-induced lethal toxicity toward ion regulation in zebrafish embryos. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 109807.
  10. Liu, S. T., Horng, J. L., Lin, L. Y., & Chou, M. Y. (2023). Fenpropathrin causes alterations in locomotion and social behaviors in zebrafish (Danio rerio). Aquatic Toxicology, 106756.
  11. Horng, J. L., Lee, Y. S., & Lin, L. Y. (2023). Exposure to silver impairs the osmoregulatory capability of euryhaline medaka (Oryzias latipes) subjected to salinity changes. Aquatic Toxicology, 260, 106592.
  12. Chou, P. H., Hu, M. Y., Guh, Y. J., Wu, G. C., Yang, S. H., Tandon, K., ... & Tseng, Y. C. (2023). Cellular mechanisms underlying extraordinary sulfide tolerance in a crustacean holobiont from hydrothermal vents. Proceedings of the Royal Society B, 290(1990), 20221973.
  13. Hung, G. Y., Pan, Y. C., Horng, J. L., & Lin, L. Y. (2023). Sublethal effects of methylmercury on lateral line sensory and ion-regulatory functions in zebrafish embryos. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 109700.
  14. Lin, L. Y., Kantha, P., & Horng, J. L. (2023). Toxic effects of polystyrene nanoparticles on the development, escape locomotion, and lateral-line sensory function of zebrafish embryos. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 109701.
  15. ST Liu, JL Horng, LY Lin* (2022) Role of the basolateral Na+/H+ exchanger-2 (NHE2) in ionocytes of seawateracclimated medaka (Oryzias latipes). Front. Physiol. 3:870967.
  16. Kantha, P., Liu, S. T., Horng, J. L., & Lin, L. Y. (2022). Acute exposure to polystyrene nanoplastics impairs skin cells and ion regulation in zebrafish embryos. Aquatic Toxicology, 106203.
  17. Hung, G. Y., Wu, C. L., Motoyama, C., Horng, J. L., & Lin, L. Y. (2022). Zebrafish embryos as an in vivo model to investigate cisplatin-induced oxidative stress and apoptosis in mitochondrion-rich ionocytes. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 109395.
  18. LY Lin, JLin Horng, CA Cheng, CY Chang, BW Cherng, ST Liu, MY Chou.2022. Sublethal ammonia induces alterations of emotions, cognition, and social behaviors in zebrafish (Danio rerio). Ecotoxicology and Environmental Safety. 244:114058.
  19. JL Horng, CY Lee, ST Liu, GY Hung, LY Lin* (2022) Differential effects of silver nanoparticles on two types of mitochondrion-rich ionocytes in zebrafish embryos. Comp. Biochem. Physiol. C Toxicol. Pharmacol., 252:109244.
  20. GY Hung, PY Chen, JL Horng, LY Lin* (2021) Vincristine exposure impairs skin keratinocytes, ionocytes, and lateral-line hair cells in developing zebrafish embryos. Aquatic Toxicology, 230, 105703
  21. CW Fu, JL Horng, SK Tong, LY Lin*, MY Chou* (2021) Exposure to silver impairs learning and social behaviors in adult zebrafish. Journal of Hazardous Materials, 403, 124031
  22. HJ Yen, JR Lin, YH Yeh, JL Horng, LY Lin* (2021) Exposure to colistin impairs skin keratinocytes and lateral-line hair cells in zebrafish embryos. Chemosphere, 263, 128364
  23. Liu, S.-T., Chou, M.-Y., Wu, L.-C., Horng, J.-L., Lin, L.-Y. 2020. Transient receptor potential vanilloid 4 modulates ion balance through the isotocin pathway in zebrafish (Danio rerio). American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 318(4), R751–R759
  24. Chou, C. M., Mi, F. L., Horng, J. L., Lin, L. Y., Tsai, M. L., Liu, C. L., ... & Cheng, C. H. (2020). Characterization and toxicology evaluation of low molecular weight chitosan on zebrafish. Carbohydrate polymers, 240, 116164.
  25. LY Lin, JA Zheng, SC Huang, GY Hung, JL Horng (2020) Ammonia exposure impairs lateral-line hair cells and mechanotransduction in zebrafish embryos. Chemosphere, 257, 127170
  26. CY Lee, JL Horng, ST Liu, LY Lin* (2020) Exposure to copper nanoparticles impairs ion uptake, and acid and ammonia excretion by ionocytes in zebrafish embryos. Chemosphere, 261, 128051
  27. Hung GY, Wu CL, Chou YL, Horng JL, Lin LY (2019) Cisplatin exposure impairs ionocytes and hair cells in the skin of zebrafish embryos. Aquatic Toxicology, 209, 168–177
  28. Hung, G. Y., Horng, J. L., Chen, P. C. H., Lin, L. Y., Chen, J. Y., Chuang, P. H., ... & Yen, C. C. (2019). Incidence of soft tissue sarcoma in Taiwan: A nationwide population-based study (2007–2013). Cancer epidemiology, 60, 185-192.
  29. Hung, G. Y., Yu, T. Y., Yen, H. J., Yang, C. F., Lin, L. Y., & Horng, J. L. (2019). Systemic Epstein-Barr Virus-positive T-Cell Lymphoma of Childhood Presentation With Hemophagocytosis. Journal of Pediatric Hematology/Oncology, 41(4), 319-320.
  30. Lee CY. Horng JL, Chen PY, Lin LY (2019) Silver nanoparticle exposure impairs ion regulation in zebrafish embryos. Aquatic Toxicology, 214, 105263
  31. Yen, H.-J., Horng, J.-L., Yu, C.-H., ...Yeh, Y.-H., Lin, L.-Y. 2019. Toxic effects of silver and copper nanoparticles on lateral-line hair cells of zebrafish embryos. Aquatic Toxicology, 215, 105273
  32. Lin, L.-Y., Hung, G.-Y., Yeh, Y.-H., Chen, S.-W., Horng, J.-L. 2019. Acidified water impairs the lateral line system of zebrafish embryos. Aquatic Toxicology, 217, 105351
  33. Hung, G.-Y., Lee, C.-Y., Yen, H.-J., Lin, L.-Y., Horng, J.-L. (2018) Incidence of immune thrombocytopenia in Taiwan: a nationwide population-based study. Transfusion, 58(11), 2712–2719
  34. Lin, L.-Y., Yeh, Y.-H., Hung, G.-Y., Hwang, P.-P., Horng, J.-L. (2018) Role of calcium-sensing receptor in mechanotransducer-channel-mediated Ca2+ influx in hair cells of zebrafish larvae. Frontiers in Physiology, 9, 649
  35. Hung, G.-Y., Lin, L.-Y., Yu, T.-Y., ...Yen, H.-J., Horng, J.-L. (2018) Hepatoblastoma incidence in Taiwan: A population-based study. Journal of the Chinese Medical Association, 81(6), 541–547
  36. Horng, J.-L., Yu, L.-L., Liu, S.-T., Chen, P.-Y., Lin, L.-Y. (2017) Potassium Regulation in Medaka (Oryzias latipes) Larvae Acclimated to Fresh Water: Passive Uptake and Active Secretion by the Skin Cells. Scientific Reports, 7(1), 16215
  37. GY Hung, CC Chen, JL Horng, LY Lin* (2016) Cancer in adolescents: incidences and trends during 1995~2009 in Taiwan. Cancer Letters, 372(1):110-117.
  38. Liu, S.-T., Horng, J.-L., Chen, P.-Y., Hwang, P.-P., Lin, L.-Y. (2016) Salt secretion is linked to acid-base regulation of ionocytes in seawater-acclimated medaka: New insights into the salt-secreting mechanism. Scientific Reports, 6, 31433
  39. Furukawa, F., Tseng, Y.-C., Liu, S.-T., ...Lin, L.-Y., Hwang, P.-P. (2015) Induction of phosphoenolpyruvate carboxykinase (PEPCK) during acute acidosis and its role in acid secretion by V-ATPase-expressing ionocytes. International Journal of Biological Sciences, 11(6), 712–725
  40. YH Lin, GY Hung, LC Wu, SW Chen, LY Lin*, JL Horng* (2015). Anion exchanger 1b in stereocilia is required for the functioning of mechanotransducer channels in lateral-line hair cells of zebrafish. PLOS ONE, 10(2):e0117041.
  41. Horng JL, Chao PL, Chen PY, Shih TH, Lin LY* (2015) Aquaporin 1 Is Involved in Acid Secretion by Ionocytes of Zebrafish Embryos through Facilitating CO2 Transport. PLoS One, 10(8):e0136440.
  42. Hung GY, Horng JL, Yen HJ, Lee CY, Lin LY* (2015) Changing incidence patterns of hepatocellular carcinoma among age groups in Taiwan. Journal of hepatology, 63(6):1390-6.
  43. Hsu HH, Lin LY, Tseng YC, Horng JL, Hwang PP (2014). A new model for fish ion regulation: identification of ionocytes in freshwater- and seawater-acclimated medaka (Oryzias latipes). Cell Tissue Res., 357(1):225-43.
  44. Liu, S. T., L. Tsung, J. L. Horng, L.Y. Lin* (2013). Proton-facilitated ammonia excretion by ionocytes of medaka (Oryzias latipes) acclimated to seawater.. Am. J. Physiol. (Regul. Integr. Comp. Physiol.), 305:242-251
  45. Lin LY, Pang W., Chuang WM, Hung GY, Lin YH, Horng JL. (2013). Extracellular Ca2+ and Mg2+ modulate aminoglycoside blockade of mechanotransducer channel-mediated Ca2+ entry in zebrafish hair cells: an in vivo study with SIET. . Am. J. Physiol. (Cell Physiol.), 305:1060-1068.
  46. YC Tseng, MY Hu, M Stumpp, LY Lin, F. Melzner, PP Hwang (2013). CO2-driven seawater acidification differentially affects development and molecular plasticity along life history of fish (Oryzias latipes).. Comp. Biochem. Physiol. A, 165:119-130.
  47. Marian YH, JR Lee, LY Lin, TH Shih, M Stumpp, MF Lee, PP Hwang and YC Tseng (2013). Development in a naturally acidified environment: Na+/H+-exchanger 3-based proton secretion leads to CO2 tolerance in cephalopod embryos. Front. Zool., 29.
  48. Tin-Han Shih, Jiun-Lin Horng, Yi-Ting Lai, Li-Yih Lin* (2013). Rhcg1 and Rhbg mediate ammonia excretion by ionocytes and keratinocytes in the skin of zebrafish larvae: H+-ATPase-linked active ammonia excretion by ionocytes. Am. J. Physiol. (Regul. Integr. Comp. Physiol.), 304(12):1130-1138.
  49. Cheng YC, MC Tu, JR Tsai, HC Lin, LY Lin* (2013). Comparison of the osmoregulatory capabilities among three amphibious sea snakes (Laticauda spp.) in Taiwan.. Zool. Stud., 52:28.
  50. Lin CC, Lin LY, Hsu HH, Thermes V, Prunet P, Horng JL, Hwang PP. (2012). Acid secretion by mitochondrion-rich cells of medaka (Oryzias latipes) acclimated to acidic fresh water.. Am. J. Physiol. (Regul. Integr. Comp. Physiol.), 302:283-291.
  51. Shih, T. H., J. L. Horng, S. T. Liu, P. P. Hwang, L. Y. Lin*. (2012). Rhcg1 and NHE3b are involved in ammonium-dependent sodium uptake by zebrafish larvae acclimated to low-sodium water.. Am. J. Physiol. (Regul. Integr. Comp. Physiol.), 302:84-93.
  52. Shen, WP, JL Horng, LY Lin* (2011) Functional plasticity of mitochondrion-rich cells in the skin of euryhaline medaka larvae (Oryzias latipes) subjected to salinity changes. . Am. J. Physiol. (Regul. Integr. Comp. Physiol.), 300:858-868.
  53. Hwang, P. P., C. H. Lee, and L. Y. Lin. (2011) Ion regulation in fish gills: recent progress in the cellular and molecular mechanisms.. Am. J. Physiol. (Regul. Integr. Comp. Physiol.), 301(6):R1700-9.
  54. Hu MY, Tseng YC, Lin LY, Chen PY, Charmantier-Daures M, Hwang PP, Melzner F. (2011). New insights into ion regulation of cephalopod molluscs: a role of epidermal ionocytes in acid-base regulation during embryogenesis.. Am. J. Physiol. (Regul. Integr. Comp. Physiol.), 301:1700-1709.
  55. SC Wu, JL Horng, PP Hwang, ZH Wen, CS Lin, LY Lin* (2010) Ammonium dependent sodium uptake in mitochondrion-rich cells of medaka (Oryzias latipes) larvae. Am. J. Physiol. (Cell Physiol.), 298: C237-250.
  56. Horng, JL, PP Hwang, TH Shih, ZH Wen, CS Lin, LY Lin* (2009) Chloride transport in mitochondrion-rich cells of euryhaline tilapia (Oreochromis mossambicus) larvae. Am. J. Physiol. (Cell Physiol.), 297:845-854.
  57. Horng#, JL, LY Lin#, PP Hwang*. (2009). Functional regulation of H+-ATPase-rich cells in zebrafish embryos acclimated to an acidic environment. . Am. J. Physiol. (Cell Physiol.), 296:682-692.
  58. Horng, J. L., and L. Y. Lin* (2008) Expression of the Na-K-2Cl cotransporter in branchial mitochondrion-rich cells of Mossambique tilapia (Oreochromis mossambicus) subjected to varying chloride conditions.. Zool. Stud., 47:733-740.
  59. Wu, S. M., H. R. Ding, L. Y. Lin, and Y. S. Lin. (2008). Juvenile tilapia (Oreochromis mossambicus) strive to maintain physiological functions after waterborne copper exposure. Arch. Environ. Contam. Toxicol, 54:482-492.
  60. Shih, T. H., J. L. Horng, P. P. Hwang and L. Y. Lin*. (2008). Ammonia excretion by the skin of zebrafish (Denio rerio) larvae.. Am. J. Physiol. (Cell Physiol.) , 295:1625-1632.
  61. JL Horng, Lin LY, PP Hwang (2007) Knockdown of V-ATPase subunit A (atp6v1a) impairs acid secretion and ion balance in zebrafish Danio rerio. Am. J. Physiol. (Regul. Integr. Comp. Physiol.), 292:R2068-2076.
  62. Lin L. Y., J. L. Horng, J. G. Kunkel, P. P. Hwang. (2006). proton pump-rich cell secrets acid in skin of zebrafish larvae. Am. J. Physiol. (Cell Physiol.), 290: C371–C378.

  1. Lin, Li-Yih, Bu-Yuan Hsiao, and Jiun-Lin Horng. 2024. "Investigating the Copper Nanoparticles Induced Cardiovascular Toxicity in Zebrafish Embryos." 11th International Conference on Biomedical and Bioinformatics Engineering (ICBBE), 8–11 Nov. 2024, Osaka, Japan.
  2. Lin, Li-Yih, Geng-Xin Kung, and Jiun-Lin Horng. 2025. "Acidification of Water Intensifies Silver-Induced Toxicity in Zebrafish Embryos." 12th International Conference on Chemical and Biological Sciences (ICCBS), 8–11 Apr. 2025, Osaka, Japan.
  3. Lin, Li-Yih. 2025. "Zebrafish-Based Assessment of Bongkrekic Acid-Induced Multiorgan Developmental Toxicity." International Conference on Food Microbiology and Food Safety (ICFMFS), 26–27 Aug. 2025, Tokyo, Japan.
  4. Lin, Li-Yih, Geng-Xin Kung, and Jiun-Lin Horng. 2024. "Acidification of Water Exacerbates Silver-Induced Toxicity in Zebrafish Embryos." 18th International Zebrafish Conference (IZFC), 17–21 Aug. 2024, Kyoto, Japan.

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