1. Devapatla P, Jeng WY, Chiu WT, Hsieh-Li HM. The pathophysiological significance between autosomal dominant polycystic kidney disease and neutrophil gelatinase-associated lipocalin. Kidney Res Clin Pract. 2025 Mar;44(2):238-248.
  2. Chiang MK, Lin TC, Lin KH, Chang YC, Hsieh-Li HM, Lai DM. Hyperbaric Oxygen Therapy Attenuated the Motor Coordination and Cognitive Impairment of Polyglutamine Spinocerebellar Ataxia SCA17 Mice. Cerebellum. 2024 Apr;23(2):401-417.
  3. Chiu YJ, Teng YS, Chen CM, Sun YC, Hsieh-Li HM, Chang KH, Lee-Chen GJ. A Neuroprotective Action of Quercetin and Apigenin through Inhibiting Aggregation of Aβ and Activation of TRKB Signaling in a Cellular Experiment. Biomol Ther (Seoul). 2023 May 1;31(3):285-297.
  4. Jalsra, A, Urtnasan M, Hsieh-Li HM* (2023, Jan) Ethanolic extract of Hedysarum Alpinum L Is rich in flavonoids and shows free radical scavenging and psychological modulation activities. Journal of Food Engineering and Technology, 12(1), 14-20.
  5. Lin CH, Hsieh YS, Sun YC, Huang WH, Chen SL, Weng ZK, Lin TH, Wu YR, Chang KH, Huang HJ, Lee GC, Hsieh-Li HM, Lee-Chen GJ. Virtual Screening and Testing of GSK-3 Inhibitors Using Human SH-SY5Y Cells Expressing Tau Folding Reporter and Mouse Hippocampal Primary Culture under Tau Cytotoxicity. Biomol Ther (Seoul). 2023 Jan 1;31(1):127-138.
  6. Chuang HY, Jeng WY, Wang E, Jiang ST, Hsu CM, Hsieh-Li HM, Chiou YY. Secreted Neutrophil Gelatinase-Associated Lipocalin Shows Stronger Ability to Inhibit Cyst Enlargement of ADPKD Cells Compared with Nonsecreted Form. Cells. 2022 Jan 30;11(3):483.
  7. Chang WF, Lin TY, Peng M, Chang CC, Xu J, Hsieh-Li HM, Liu JL, Sung LY. Survival Motor Neuron Enhances Pluripotent Gene Expression and Facilitates Cell Reprogramming. Stem Cells Dev. 2022 Aug 23.
  8. Chiu YJ, Lin TH, Chang KH, Lin W, Hsieh-Li HM, Su MT, Chen CM, Sun YC, Lee-Chen GJ. Novel TRKB agonists activate TRKB and downstream ERK and AKT signaling to protect Aβ-GFP SH-SY5Y cells against Aβ toxicity. Aging (Albany NY). 2022 Sep 26;14(18):7568-7586.
  9. Chiu YJ, Lin TH, Chen CM, Lin CH, Teng YS, Lin CY, Sun YC, Hsieh-Li HM, Su MT, Lee-Chen GJ, Lin W, Chang KH. Novel Synthetic Coumarin-Chalcone Derivative (E)-3-(3-(4-(Dimethylamino)Phenyl)Acryloyl)-4-Hydroxy-2H-Chromen-2-One Activates CREB-Mediated Neuroprotection in Aβ and Tau Cell Models of Alzheimer's Disease. Oxid Med Cell Longev. 2021 Nov 13;2021:3058861.
  10. Lee YS, Lai DM, Huang HJ, Lee-Chen GJ, Chang CH, Hsieh-Li HM, Lee GC. Prebiotic Lactulose Ameliorates the Cognitive Deficit in Alzheimer's Disease Mouse Model through Macroautophagy and Chaperone-Mediated Autophagy Pathways. J Agric Food Chem. 2021 Mar 3;69(8):2422-2437.
  11. Chiang NN, Lin TH, Teng YS, Sun YC, Chang KH, Lin CY, Hsieh-Li HM, Su MT, Chen CM, Lee-Chen GJ. Flavones 7,8-DHF, Quercetin, and Apigenin Against Tau Toxicity via Activation of TRKB Signaling in ΔK280 TauRD-DsRed SH-SY5Y Cells. Front Aging Neurosci. 2021 Dec 15;13:758895.
  12. Chiu YJ, Lin CH, Lee MC, Hsieh-Li HM, Chen CM, Wu YR, Chang KH, Lee-Chen GJ. Formulated Chinese medicine Shaoyao Gancao Tang reduces NLRP1 and NLRP3 in Alzheimer's disease cell and mouse models for neuroprotection and cognitive improvement. Aging (Albany NY). 2021 Jun 9;13(11):15620-15637.
  13. Huang HJ, Chen JL, Liao JF, Chen YH, Chieu MW, Ke YY, Hsu CC, Tsai YC, Hsieh-Li HM. Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer's disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis. BMC Complement Med Ther. 2021 Oct 9;21(1):259.
  14. Huang CC, Chang KH, Chiu YJ, et al. Multi-Target Effects of Novel Synthetic Coumarin Derivatives Protecting Aβ-GFP SH-SY5Y Cells against Aβ Toxicity. Cells. 2021;10(11):3095.
  15. Chang WF, Peng M, Hsu J, Xu J, Cho HC, Hsieh-Li HM, Liu JL, Lu CH, Sung LY. Effects of Survival Motor Neuron Protein on Germ Cell Development in Mouse and Human. Int J Mol Sci. 2021 Jan 11;22(2):661.
  16. Chung YH, Lin CW, Huang HY, Chen SL, Huang HJ, Sun YC, Lee GC, Lee-Chen GJ, Chang YC, Hsieh-Li HM. Targeting Inflammation, PHA-767491 Shows a Broad Spectrum in Protein Aggregation Diseases. J Mol Neurosci. 2020 Jul;70(7):1140-1152. doi: 10.1007/s12031-020-01521-y. Epub 2020 Mar 13. PMID: 32170713.
  17. Chang WF, Xu J, Lin TY, Hsu J, Hsieh-Li HM, Hwu YM, Liu JL, Lu CH, Sung LY. Survival Motor Neuron Protein Participates in Mouse Germ Cell Development and Spermatogonium Maintenance. Int J Mol Sci. 2020 Jan 25;21(3):794. doi: 10.3390/ijms21030794. PMID: 31991812; PMCID: PMC7037566.
  18. Liao JF, Cheng YF, You ST, Kuo WC, Huang CW, Chiou JJ, Hsu CC, Hsieh-Li HM, Wang S, Tsai YC. Lactobacillus plantarum PS128 alleviates neurodegenerative progression in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse models of Parkinson's disease. Brain Behav Immun. 2020 Nov;90:26-46. doi: 10.1016/j.bbi.2020.07.036. Epub 2020 Jul 30. PMID: 32739365.
  19. Lin CW, Fan CH, Chang YC, Hsieh-Li HM. ERK activation precedes Purkinje cell loss in mice with Spinocerebellar ataxia type 17. Neurosci Lett. 2020 Nov 1;738:135337. doi: 10.1016/j.neulet.2020.135337. Epub 2020 Aug 30. PMID: 32877710.
  20. Chen CC, Yao NW, Lin CW, Su WS, Wu CT, Chang C, Hsieh-Li HM. Neuroimaging Spectrum at Pre-, Early, and Late Symptomatic Stages of SCA17 Mice. Cerebellum. 2020 Aug;19(4):487-500. doi: 10.1007/s12311-020-01127-5. PMID: 32270465.
  21. Fan CH, Lin CW, Huang HJ, Lee-Chen GJ, Sun YC, Lin W, Chen CM, Chang KH, Su MT, Hsieh-Li HM. LMDS-1, a potential TrkB receptor agonist provides a safe and neurotrophic effect for early-phase Alzheimer's disease. Psychopharmacology (Berl). 2020 Oct;237(10):3173-3190. doi: 10.1007/s00213-020-05602-z. Epub 2020 Aug 4. PMID: 32748031.
  22. Chiu YJ, Hsieh YH, Lin TH, Lee GC, Hsieh-Li HM, Sun YC, Chen CM, Chang KH, Lee-Chen GJ. Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease. Neurochem Int. 2019 May;125:175-186.
  23. Puerariae Radix Prevents Anxiety and Cognitive Deficits in Mice under Oligomeric Aβ-Induced Stress 2019 American Journal of Chinese Medicine 47(7),
  24. Huang HJ, Chen SL, Huang HY, Sun YC, Lee GC, Lee-Chen GJ, Hsieh-Li HM, Su MT (2018, Nov). Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice. Psychopharmacology.
  25. Chen YC, Chiu YJ, Lin CH, Hsu WC, Wu JL, Huang CH, Lin CW, Yao CF, Huang HJ, Lo YS, Chen CM, Wu YR, Chang KH, Lee-Chen GJ, Mei Hsieh-Li H. Indole Compound NC009-1 Augments APOE and TRKA in Alzheimer's Disease Cell and Mouse Models for Neuroprotection and Cognitive Improvement. J Alzheimers Dis. 2019;67(2):737-756. doi: 10.3233/JAD-180643. PMID: 30689566.
  26. Huang HJ, Huang HY, Hsieh-Li HM (2018, Jul). Huang HJ, Huang HY, Hsieh-Li HM. MGCD0103, a selective histone deacetylase inhibitor, coameliorates oligomeric Aβ(25-35) -induced anxiety and cognitive deficits in a mouse model. CNS Neurosci Ther.
  27. Chen CM, Chen WL, Hung CT, Lin TH, Lee MC, Chen IC, Lin CH, Chao CY, Wu YR, Chang KH, Hsieh-Li HM, Lee-Chen GJ. Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models. Aging (Albany NY). 2019 Feb 13;11(3):986-1007. doi: 10.18632/aging.101804. PMID: 30760647; PMCID: PMC6382417.
  28. Chen CM, Chen WL, Hung CT, Lin TH, Chao CY, Lin CH, Wu YR, Chang KH, Yao CF, Lee-Chen GJ, Su MT, Hsieh-Li HM. The indole compound NC009-1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice. Neurotoxicology. 2018 Jul;67:259-269. doi: 10.1016/j.neuro.2018.06.009. Epub 2018 Jun 21. PMID: 29936316.
  29. Huang HJ, Chen SL, Chang YT, Chyuan JH, Hsieh-Li HM (2018, Dec).Administration of Momordica charantia enhances the neuroprotection and reduces the side effects of LiCl in the treatment of Alzheimer's Disease. Nutrients, 10(12): E1888.
  30. Lin TS, Tsai HJ, Lee CH, Song YQ, Huang RS, Hsieh-Li HM, Liang MC, Lin Y. An Improved Drugs Screening System Reveals that Baicalein Ameliorates the Aβ/AMPA/NMDA-Induced Depolarization of Neurons. J Alzheimers Dis. 2017;56(3):959-976. doi: 10.3233/JAD-160898. PMID: 28106556.
  31. Hsu CJ, Hsu WC, Lee DJ, Liu AL, Chang CM, Shih HJ, Huang WH, Lee-Chen GJ, Hsieh-Li HM, Lee GC, Sun YC. Investigation of the bindings of a class of inhibitors with GSK3β kinase using thermodynamic integration MD simulation and kinase assay. Chem Biol Drug Des. 2017 Aug;90(2):272-281. doi: 10.1111/cbdd.12946. Epub 2017 Mar 6. PMID: 28127860.
  32. Chang KH, Lin CH, Chen HC, Huang HY, Chen SL, Lin TH, Ramesh C, Huang CC, Fung HC, Wu YR, Huang HJ, Lee-Chen GJ, Hsieh-Li HM, Yao CF. The Potential of Indole/Indolylquinoline Compounds in Tau Misfolding Reduction by Enhancement of HSPB1. CNS Neurosci Ther. 2017 Jan;23(1):45-56. doi: 10.1111/cns.12592. Epub 2016 Jul 18. PMID: 27424519; PMCID: PMC6492720.
  33. Wang E, Chiou YY, Jeng WY, Lin HK, Lin HH, Chin HJ, Leo Wang CK, Yu SS, Tsai SC, Chiang CY, Cheng PH, Lin HJ, Jiang ST, Chiu ST, Hsieh-Li HM. Overexpression of exogenous kidney-specific Ngal attenuates progressive cyst development and prolongs lifespan in a murine model of polycystic kidney disease. Kidney Int. 2017 Feb;91(2):412-422. doi: 10.1016/j.kint.2016.09.005. Epub 2016 Oct 27. PMID: 28341240.
  34. Chang YC, Lin CW, Hsu CM, Lee-Chen GJ, Su MT, Ro LS, Chen CM, Huang HJ, Hsieh-Li HM. Targeting the prodromal stage of spinocerebellar ataxia type 17 mice: G-CSF in the prevention of motor deficits via upregulating chaperone and autophagy levels. Brain Res. 2016 May 15;1639:132-48. doi: 10.1016/j.brainres.2016.03.004. Epub 2016 Mar 10. PMID: 26972528.
  35. Chang KH, Chiu YJ, Chen SL, Huang CH, Lin CH, Lin TH, Lee CM, Ramesh C, Wu CH, Huang CC, Fung HC, Chen YC, Lin JY, Yao CF, Huang HJ, Lee-Chen GJ, Lee MC, Hsieh-Li HM. The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity. Neuropharmacology. 2016 Feb;101:309-19.
  36. Chang WF, Xu J, Chang CC, Yang SH, Li HY, Hsieh-Li HM, Tsai MH, Wu SC, Cheng WT, Liu JL, Sung LY. SMN is required for the maintenance of embryonic stem cells and neuronal differentiation in mice. Brain Struct Funct. 2014 Mar 17. [Epub ahead of print]
  37. Huang HJ, Chen SL, Hsieh-Li HM. Administration of NaHS Attenuates Footshock-Induced Pathologies and Emotional and Cognitive Dysfunction in Triple Transgenic Alzheimer's Mice. Front Behav Neurosci. 2015 Nov 25;9:312.
  38. Chen ZZ, Wang CM, Lee GC, Hsu HC, Wu TL, Lin CW, Ma CK, Lee-Chen GJ, Huang HJ, Hsieh-Li HM. Trehalose attenuates the gait ataxia and gliosis of spinocerebellar ataxia type 17 mice. Neurochem Res. 2015 Apr;40(4):800-10.
  39. Lee GC, Lin CH, Tao YC, Yang JM, Hsu KC, Huang YJ, Huang SH, Kung PJ, Chen WL, Wang CM, Wu YR, Chen CM, Lin JY, Hsieh-Li HM, Lee-Chen GJ. The potential of lactulose and melibiose, two novel trehalase-indigestible and autophagy-inducing disaccharides, for polyQ-mediated neurodegenerative disease treatment. Neurotoxicology. 2015 May;48:120-30.
  40. Huang HJ, Chen WL, Hsieh RH, Hsieh-Li HM. Multifunctional Effects of Mangosteen Pericarp on Cognition in C57BL/6J and Triple Transgenic Alzheimer's Mice. Evid Based Complement Alternat Med. 2014;2014:813672.
  41. Kung PJ, Tao YC, Hsu HC, Chen WL, Lin TH, Janreddy D, Yao CF, Chang KH, Lin JY, Su MT, Wu CH, Lee-Chen GJ, Hsieh-Li HM. Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models. Drug Des Devel Ther. 2014 Oct 16;8:1929-39.
  42. Chen IC, Lin HY, Hsiao YC, Chen CM, Wu YR, Shiau HC, Shen YF, Huang KS, Su MT, Hsieh-Li HM, Lee-Chen GJ. Internal ribosome entry segment activity of ATXN8 opposite strand RNA. PLoS One. 2013 Sep 11;8(9):e73885.
  43. Liu HC, Ting CH, Wen HL, Tsai LK, Hsieh-Li HM, Li H, Lin-Chao S. Sodium vanadate combined with L-ascorbic acid delays disease progression, enhances motor performance, and ameliorates muscle atrophy and weakness in mice with spinal muscular atrophy. BMC Med. 2013 Feb 14;11:38.
  44. Huang HJ, Chen YH, Liang KC, Jheng YS, Jhao JJ, Su MT, Lee-Chen GJ, Hsieh-Li HM. Exendin-4 protected against cognitive dysfunction in hyperglycemic mice receiving an intrahippocampal lipopolysaccharide injection. PLoS One. 2012;7(7):e39656.
  45. Lee LC, Chen CM, Wang HC, Hsieh HH, Chiu IS, Su MT, Hsieh-Li HM, Wu CH, Lee GC, Lee-Chen GJ, Lin JY. Role of the CCAAT-binding protein NFY in SCA17 pathogenesis. PLoS One. 2012;7(4):e35302. doi: 10.1371/journal.pone.0035302. Epub 2012 Apr 17. PMID: 22530004; PMCID: PMC3328435.
  46. Ting CH, Wen HL, Liu HC, Hsieh-Li HM, Li H, Lin-Chao S. The spinal muscular atrophy disease protein SMN is linked to the Golgi network. PLoS One. 2012;7(12):e51826.
  47. Wang TC, Fang CN, Shen CC, Wei HY, Weng YP, Lin JY, Hsieh-Li HM, Lee CY. Yang-Dan-Tang, Identified from 15 Chinese Herbal Formulae, Inhibits Human Lung Cancer Cell Proliferation via Cell Cycle Arrest. Evid Based Complement Alternat Med. 2012;2012:276032.
  48. Ke HC, Huang HJ, Liang KC, Hsieh-Li HM. Selective improvement of cognitive function in adult and aged APP/PS1 transgenic mice by continuous non-shock treadmill exercise. Brain Res. 2011 Jul 27;1403:1-11.
  49. Lin YT, Chern Y, Shen CK, Wen HL, Chang YC, Li H, Cheng TH, Hsieh-Li HM. Human mesenchymal stem cells prolong survival and ameliorate motor deficit through trophic support in Huntington's disease mouse models. PLoS One. 2011;6(8):e22924.
  50. Chang YC, Lin CY, Hsu CM, Lin HC, Chen YH, Lee-Chen GJ, Su MT, Ro LS, Chen CM, Hsieh-Li HM. Neuroprotective effects of granulocyte-colony stimulating factor in a novel transgenic mouse model of SCA17. J Neurochem. 2011 Jul;118(2):288-303.
  51. Huang HJ, Liang KC, Ke HC, Chang YY, Hsieh-Li HM. Long-term social isolation exacerbates the impairment of spatial working memory in APP/PS1 transgenic mice. Brain Res. 2011 Jan 31;1371:150-60.
  52. Wang YC, Lee CM, Lee LC, Tung LC, Hsieh-Li HM, Lee-Chen GJ, Su MT. Mitochondrial dysfunction and oxidative stress contribute to the pathogenesis of spinocerebellar ataxia type 12 (SCA12). J Biol Chem. 2011 Jun 17;286(24):21742-54. doi: 10.1074/jbc.M110.160697. Epub 2011 Apr 6. PMID: 21471219; PMCID: PMC3122230.
  53. Wen HL, Lin YT, Ting CH, Lin-Chao S, Li H, Hsieh-Li HM. Stathmin, a microtubule-destabilizing protein, is dysregulated in spinal muscular atrophy. Hum Mol Genet. 2010 May 1;19(9):1766-78.
  54. Wang E, Hsieh-Li HM, Chiou YY, Chien YL, Ho HH, Chin HJ, Wang CK, Liang SC, Jiang ST. Progressive renal distortion by multiple cysts in transgenic mice expressing artificial microRNAs against Pkd1. J Pathol. 2010 Nov;222(3):238-48.
  55. Wu SL, Tsai MS, Wong SH, Hsieh-Li HM, Tsai TS, Chang WT, Huang SL, Chiu CC, Wang SH. Characterization of genomic structures and expression profiles of three tandem repeats of a mouse double homeobox gene: Duxbl. Dev Dyn. 2010 Mar;239(3):927-40.
  56. Huang HJ, Liang KC, Chang YY, Ke HC, Lin JY, Hsieh-Li HM. The interaction between acute oligomer Abeta(1-40) and stress severely impaired spatial learning and memory. Neurobiol Learn Mem. 2010 Jan;93(1):8-18.
  57. Chen WL, Lin JW, Huang HJ, Wang SM, Su MT, Lee-Chen GJ, Chen CM, Hsieh-Li HM. SCA8 mRNA expression suggests an antisense regulation of KLHL1 and correlates to SCA8 pathology. Brain Res. 2008 Oct 3;1233:176-84. doi: 10.1016/j.brainres.2008.07.096. Epub 2008 Aug 3. PMID: 18708037.
  58. Peng CC, Chen KC, Peng RY, Chyau CC, Su CH, Hsieh-Li HM. Antrodia camphorata extract induces replicative senescence in superficial TCC, and inhibits the absolute migration capability in invasive bladder carcinoma cells. J Ethnopharmacol. 2007 Jan 3;109(1):93-103. doi: 10.1016/j.jep.2006.07.009. Epub 2006 Jul 11. PMID: 16930895.
  59. Cheng WC, Hsieh-Li HM, Yeh YJ, Li H. Mice lacking the Obox6 homeobox gene undergo normal early embryonic development and are fertile. Dev Dyn. 2007 Sep;236(9):2636-42. doi: 10.1002/dvdy.21261. PMID: 17676645.
  60. Huang HJ, Liang KC, Chen CP, Chen CM, Hsieh-Li HM. Intrahippocampal administration of A beta(1-40) impairs spatial learning and memory in hyperglycemic mice. Neurobiol Learn Mem. 2007 May;87(4):483-94. doi: 10.1016/j.nlm.2006.11.006. Epub 2007 Jan 22. PMID: 17241793.
  61. Chen KC, Peng CC, Peng RY, Su CH, Chiang HS, Yan JH, Hsieh-Li HM. Unique formosan mushroom Antrodia camphorata differentially inhibits androgen-responsive LNCaP and -independent PC-3 prostate cancer cells. Nutr Cancer. 2007;57(1):111-21. doi: 10.1080/01635580701268360. PMID: 17516868.
  62. Peng CC, Chen KC, Peng RY, Su CH, Hsieh-Li HM. Human urinary bladder cancer T24 cells are susceptible to the Antrodia camphorata extracts. Cancer Lett. 2006 Nov 8;243(1):109-19. doi: 10.1016/j.canlet.2005.11.021. Epub 2006 Feb 7. PMID: 16455193.

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多麩醯胺小腦萎縮症/阿茲海默氏症的藥物開發－(子計畫三)以HDAC inhibitors為目標的多麩醯胺小腦萎縮症及阿茲海默氏症治療策略(3/3) 2016/05/01 2017/04/30 科技部(原國科會) MOST 105-2325-B-003-003 主持人
第十七型脊髓小腦萎縮症神經發炎機制與因應治療策略之研究(第1年) 2015/08/01 2016/07/31 科技部(原國科會) MOST 104-2320-B-003 -009 -MY3 (1st yr) 主持人
多麩醯胺小腦萎縮症/阿茲海默氏症的藥物開發－(子計畫三)以HDAC inh ibitors為目標的多麩醯胺小腦萎縮症及阿茲海默氏症治療策略(2/3) 2015/05/01 2016/04/30 科技部(原國科會) MOST 104-2325-B-003-003 主持人
阿茲海默氏症的治療策略—從基因到行為,－以阿茲海默氏症小鼠模式評 估GSK3抑制劑之治療潛力—奠基於電腦輔助藥物設計及激酶生化檢測(2/2) 2014/08/01 2015/07/31 國科會 MOST 103-2321-B-003 -003 總主持人
多麩醯胺小腦萎縮症/阿茲海默氏症的藥物開發－(子計畫三)以HDAC inhibitors 為目標的多麩醯胺小腦萎縮症及阿茲海默氏症治療策略(1/3) 2014/05/01 2015/04/30 國科會 MOST 103-2325-B003-003 主持人
阿茲海默氏症的治療策略—從基因到行為－以阿茲海默氏症小鼠模式評估GSK3抑制劑之治療潛力—奠基於電腦輔助藥物設計及激酶生化檢測(1/2) 2013/08/01 2014/07/31 國科會 NSC 102-2321-B-003 -004 總主持人
多麩醯胺小腦萎縮症的藥物篩檢－(子計畫六)新穎HDACinhibitors療效評估研究；核心實驗室4：多麩醯胺小腦萎縮症轉殖果蠅與小鼠動物模式(3/3) 2013/05/01 2014/04/30 國科會 NSC 102-2325-B-003-001 主持人
多麩醯胺小腦萎縮症的藥物篩檢－(子計畫六)新穎HDACinhibitors療效評估研究核心實驗室4; 多麩醯胺小腦萎縮症轉殖果蠅與小鼠動物模式(2/3) 2012/05/01 2013/04/30 國科會 NSC 101-2325-B-003-001 主持人
多麩醯胺小腦萎縮症的藥物篩檢－(子計畫六)新穎HDACinhibitors療效評估研究核心實驗室4：多麩醯胺小腦萎縮症轉殖果蠅與小鼠動物模式(1/3) 2011/05/01 2012/04/30 國科會 NSC 100-2325-B-003 -002 主持人
以細胞及小鼠模式研究ATXN8OS基因三核酸重複之毒性 2010/08/01 2011/07/31 國科會 NSC 97-2320-B-003-003-MY3 (3/3) 主持人
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第十七型脊髓小腦萎縮症：以小鼠及初級培養模式探討鈣離子恆定及藥物篩檢 2009/08/01 2010/07/31 國科會 NSC 97-2311-B-003-007-MY3 (2/3) 主持人
以細胞及小鼠模式研究ATXN8OS基因三核酸重複之毒性 2009/08/01 2010/07/31 國科會 NSC 97-2320-B-003-003-MY3 (2/3) 主持人
以細胞及小鼠模式研究ATXN8OS基因三核酸重複之毒性 2008/08/01 2009/07/31 國科會 NSC 97-2320-B-003-003-MY3 (1/3) 主持人
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神經退化性疾病：多麩醯胺脊髓小腦萎縮症生物指標/致病機轉/藥物發展－多麩醯胺居間的神經退化疾病候選藥物篩檢—以SCA17細胞和小鼠為模式系統 2007/08/01 2008/07/31 國科會 NSC 96-2311-B-003-002 主持人
PPP2R2B在神經退化性疾病的功能研究－PPP2R2B 過量表現與CAG重複擴增knock-in小鼠之建立以及其神經病理與分子層次之研究 2007/08/01 2008/07/31 NSC 95-2311-B-003-005-MY2 (2/2) 主持人
人類退化性神經疾病之致病機制-第十七型脊髓小腦運動失調症－第十七型脊髓小腦運動失調症三核甘酸擴增的動物模式研究(2/2) 2006/08/01 2007/07/31 國科會 NSC95-2320-B-003-002 主持人
PPP2R2B在神經退化性疾病的功能研究－PPP2R2B 過量表現與CAG重複擴增knock-in小鼠之建立以及其神經病理與分子層次之研究 2006/08/01 2007/07/31 國科會 NSC 95-2311-B-003-005-MY2 (1/2) 主持人
Tpros基因在生精過程中功能之探討(3/3) 2005/08/01 2006/07/31 科技部(原國科會) 94-2311-B-003-001- 主持人
人類退化性神經疾病之致病機制-第十七型脊髓小腦運動失調症－第十七型脊髓小腦運動失調症三核甘酸擴增的動物模式研究(1/2) 2005/08/01 2006/07/31 國科會 NSC94-2320-B-003-006 主持人
Tpros基因在生精過程中功能之探討(2/3) 2004/08/01 2005/07/31 科技部(原國科會) 93-2311-B-003-001- 主持人
小鼠睪丸專一性同源箱基因Tex1之功能分析(3/3) 2004/08/01 2005/07/31 科技部(原國科會) 93-2320-B-003-006- 主持人
小鼠睪丸專一性同源箱基因Tex1之功能分析(2/3) 2003/08/01 2004/07/31 科技部(原國科會) 92-2320-B-003-004- 主持人
Tpros基因在生精過程中功能之探討(1/3) 2003/08/01 2004/07/31 科技部(原國科會) 92-2311-B-003-010- 主持人
睪丸專一表現同源箱基因-TSX1之分子及功能性探討(3/3) 2002/08/01 2003/07/31 科技部(原國科會) 91-2320-B-038-009- 主持人
小鼠睪丸專一性同源箱基因Tex1之功能分析(1/3) 2002/08/01 2003/07/31 科技部(原國科會) 91-2320-B-038-023- 主持人
睪丸專一表現同源箱基因-TSX1之分子及功能性探討(2/3) 2001/08/01 2002/07/31 科技部(原國科會) 90-2320-B-038-054- 主持人
睪丸專一表現同源箱基因-TSX1之分子及功能性探討(1/3) 2000/08/01 2001/07/31 科技部(原國科會) 89-2320-B-038-066- 主持人