1. Lai YJ, Sung YT, Lai YA, Chen LN, Chen TS, Chien CT*. L-Theanine-Treated Adipose-Derived Mesenchymal Stem Cells Alleviate the Cytotoxicity Induced by N-Nitrosodiethylamine in Liver. Tissue Eng Regen Med. 2022 Dec;19(6):1207-1221. (SCI, Scopus)
  2. Chung CH, Chung SD, Cheng YH, Yang CP, Chien CT*. Long-Lasting Exendin-4-Loaded PLGA Nanoparticles Ameliorate Cerebral Ischemia/Reperfusion Damage in Diabetic Rats. J Pers Med. 2022 Mar 3;12(3):390.
  3. Yang, C.-C., Liao, P.-H., Cheng, Y.-H., Chien, C.-Y., Chien, C.-T. Diabetes associated with hypertension exacerbated oxidative stress-mediated inflammation, apoptosis and autophagy leading to erectile dysfunction in rats
  4. Intrarenal Arterial Transplantation of Dexmedetomidine Preconditioning Adipose Stem-Cell-Derived Microvesicles Confers Further Therapeutic Potential to Attenuate Renal Ischemia/Reperfusion Injury through miR-122-5p/Erythropoietin/Apoptosis Axis.
  5. Chen TS, Lai YA, Lai YJ, Chien CT*. Adipose stem cells pre-incubated with theanine exert liver regeneration through in-crease of stem cell paracrine VEGF and suppression of ROS, pyroptosis as well as autophagy markers in liver damage in-duced by N-nitrosodiethylamine. Life Sci. 2022 Nov 1;308:120969. (SCI, Scopus)
  6. Wu CC, Cheng YH, Chen KH, Chien CT*. Deep Sea Water-Dissolved Organic Matter Intake Improves Hyperlipidemia and Inhibits Thrombus Formation and Vascular Inflammation in High-Fat Diet Hamsters. Life (Basel). 2022 Jan 7;12(1):82. (SCI, Scopus)
  7. Hsu, S.-P., Chien, C.-T. Reference Intervals of Spot Urine Creatinine-To-Osmolality Ratio as a Surrogate of Urinary Creatinine Excretion Rate
  8. Silicon-containing water intake confers antioxidant effect, gastrointestinal protection, and gut microbiota modulation in the rodents.
  9. Urothelial Calcium‑Sensing Receptor Modulates Micturition Function via Mediating Detrusor Activity and Ameliorates Bladder Hyperactivity in Rats
  10. Green Tea Polyphenol Catechins Inhibit Coronavirus Replication and Potentiate the Adaptive Immunity and Autophagy-Dependent Protective Mechanism to Improve Acute Lung Injury in Mice.
  11. Adipose-Derived Stem Cells and Their Derived Microvesicles Ameliorate Detrusor Overactivity Secondary to Bilateral Partial Iliac Arterial Occlusion-Induced Bladder Ischemia
  12. Sodium Thiosulfate Ameliorates Renovascular Hypertension-Induced Renal Dysfunction and Injury in Rats
  13. Sweet Potato Leaf Feeding Decreases Cholesterol, Oxidative Stress and Thrombosis Formation in Syrian Hamsters with a High-Cholesterol Diet
  14. Repetitively hypoxic preconditioning attenuates ischemia/reperfusion-induced liver dysfunction through upregulation of hypoxia-induced factor-1 alpha-dependent mitochondrial Bcl-xl in rat. Chou PL, Chen KH, Chang TC, Chien CT.
  15. Diabetes Upregulates Oxidative Stress and Downregulates Cardiac Protection to Exacerbate Myocardial Ischemia/Reperfusion Injury in Rats.
  16. Chueh TH, Cheng YH, Chen KH, Chien CT*. Thromboxane A2 Synthase and Thromboxane Receptor Deletion Reduces Ischaemia/Reperfusion-Evoked Inflammation, Apoptosis, Autophagy and Pyroptosis. Thromb Haemost. 2020 Feb;120(2):329-343.
  17. Chen YH, Chiang CY, Chang TC, Chien CT*. Multiple Progressive Thermopreconditioning Improves Cardiac Ischemia/Reperfusion Induced Left Ventricular Contractile Dysfunction and Structural Abnormality in Rat. Transplantation. 2020 Feb 13.
  18. Chang HH, Hsu SP, Chien CT*. Intrarenal Transplantation of Hypoxic Preconditioned Mesenchymal Stem Cells Improves Glomerulonephritis through Anti-Oxidation, Anti-ER Stress, Anti-Inflammation, Anti-Apoptosis, and Anti-Autophagy. Antioxidants (Basel). 2019 Dec 18;9(1).
  19. Lee SP, Wu WY, Hsiao JK, Zhou JH, Chang HH, Chien CT*. Aromatherapy: Activating olfactory calcium-sensing receptors impairs renal hemodynamics via sympathetic nerve-mediated vasoconstriction. Acta Physiol (Oxf). 2019 Jan;225(1):e13157.
  20. Wu KC, Lin WY, Sung YT, Wu WY, Cheng YH, Chen TS, Chiang BJ, Chien CT*. Glycine tomentella hayata extract and its ingredient daidzin ameliorate cyclophosphamide-induced hemorrhagic cystitis and oxidative stress through the action of antioxidation, anti-fibrosis, and anti-inflammation. Chin J Physiol. 2019 Sep-Oct;62(5):188-195.
  21. Lin CF, Chueh TH, Chung CH, Chung SD, Chang TC, Chien CT*. Sulforaphane improves voiding function via the preserving mitochondrial function in diabetic rats. J Formos Med Assoc. 2019 Dec 11
  22. Hung GY, Wu CL, Chou YL, Chien CT, Horng JL, Lin LY. Cisplatin exposure impairs ionocytes and hair cells in the skin of zebrafish embryAquat Toxicol. 2019 Apr;209:168-177.os.
  23. Wu KC, Chiang BJ, Tsai WH, Chung SD, Chien CT. I-Tiao-Gung extract through its active component daidzin improves cyclophosphamide-induced bladder dysfunction in rat model. Neurourol Urodyn. 2018 Sep 3.
  24. Genetic Depletion of Thromboxane A2/Thromboxane-Prostanoid Receptor Signalling Prevents Microvascular Dysfunction in Ischaemia/Reperfusion Injury. Chiang CY, Chien CY, Qiou WY, Chang C, Yu IS, Chang PY, Chien CT. Thromb Haemost.
  25. Aromatherapy: Activating Olfactory Calcium-sensing Receptors Impairs Renal Hemodynamics via Sympathetic Nerve-mediated Vasoconstriction Acta Physiol (Oxf). 2018 Jun 25:e13157.
  26. Tsai WH, Wu CH, Yu HJ, Chien CT. l-Theanine inhibits proinflammatory PKC/ERK/ICAM-1/IL-33 signaling, apoptosis, and autophagy formation in substance P-induced hyperactive bladder in rats. Neurourol Urodyn. 2016 Feb 1. doi: 10.1002/nau.22965.
  27. Tien AJ, Chien CY, Chen YH, Lin LC, Chien CT (Corresponding author). Fruiting Bodies of Antrodia cinnamomea and Its Active Triterpenoid, Antcin K, Ameliorates N-Nitrosodiethylamine-Induced Hepatic Inflammation, Fibrosis and Carcinogenesis in Rats. Am J Chin Med. 2017;45(1):173-198. doi: 10.1142/S0192415X17500124
  28. Yao CA, Ortiz-Vega S, Sun YY, Chien CT, Chuang JH, Lin Y. Association of mSin1 with mTORC2 Ras and Akt reveals a crucial domain on mSin1 involved in Akt phosphorylation.
  29. Tai HC, Chung SD, Chien CT*, Yu HJ. Sulforaphane Improves Ischemia-Induced Detrusor Overactivity by Downregulating the Enhancement of Associated Endoplasmic Reticulum Stress, Autophagy, and Apoptosis in Rat Bladder. Sci Rep. 2016 Nov 8;6:36110. doi: 10.1038/srep36110.
  30. Tien AJ, Chueh TH, Hsia CP, Chien CT*. Monascus Adlay and Monacolin K Attenuates Arterial Thrombosis in Rats through the Inhibition of ICAM-1 and Oxidative Stress. Kidney Blood Press Res. 2016;41(6):815-827.
  31. Hsu SP, Chen CC, Chien CT. Pretreatment of Sialic Acid Efficiently Prevents Lipopolysaccharide-Induced Acute Renal Failure and Suppresses TLR4/gp91-Mediated Apoptotic Signaling. Kidney Blood Press Res. 2016 May 10;41(3):267-277.
  32. Wu CY, Cheng YJ, Liu YJ, Wu TT, Chien CT, Chan KC; NTUH Center of Microcirculation Medical Research (NCMMR). Predicting stroke volume and arterial pressure fluid responsiveness in liver cirrhosis patients using dynamic preload variables: A prospective study of diagnostic accuracy.Eur J Anaesthesiol. 2016 May 10. [Epub ahead of print]
  33. Yao CA, Chen CC, Wang NP, Chien CT. Soy-Based Multiple Amino Acid Oral Supplementation Increases the Anti-Sarcoma Effect of Cyclophosphamide. Nutrients. 2016 Apr 1;8(4). pii: E192. doi: 10.3390/nu8040192.
  34. Lin CF, Kuo YT, Chen TY, Chien CT.Quercetin-Rich Guava (Psidium guajava) Juice in Combination with Trehalose Reduces Autophagy, Apoptosis and Pyroptosis Formation in the Kidney and Pancreas of Type II Diabetic Rats. Molecules. 2016 Mar 10;21(3). pii: E334. doi: 10.3390/molecules21030334.
  35. Tsai WH, Wu CH, Cheng CH, Chien CT. Ba-Wei-Di-Huang-Wan through its active ingredient loganin counteracts substance P-enhanced NF-κB/ICAM-1 signaling in rats with bladder hyperactivity. Neurourol Urodyn. 2015 Aug 19. doi: 10.1002/nau.22816. [Epub ahead of print]
  36. Chiang-Ting Chien, PhD1; Ming-Jia Jou, PhD2; Tai-Yu Cheng, BSc1,3; Chih-Hui Yang, PhD4; Tzu-Ying Yu, PhD5; Ping-Chia Li, PhD5*Exendin-4-Loaded PLGA Microspheres Relieve Cerebral Ischemia/Reperfusion Injury and Neurologic Deficits Through Long-Lasting Bioactivity-Mediated Phosphorylated Akt/eNOS Signaling in Rats
  37. Wu CY, Chan KC, Cheng YJ, Yeh YC, Chien CT; NTUH Center of Microcirculation Medical Research. Effects of different types of fluid resuscitation for hemorrhagic shock on splanchnic organ microcirculation and renal reactive oxygen species formation. Crit Care. 2015 Dec 11;19:434. doi: 10.1186/s13054-015-1135-y.
  38. Wu, C.-Y., Yeh, Y.-C., Chien, C.-T., (...), Sun, W.-Z., Cheng, Y.-J.Laser speckle contrast imaging for assessing microcirculatory changes in multiple splanchnic organs and the gracilis muscle during hemorrhagic shock and fluid resuscitation
  39. Yang CC, Yao CA, Yang JC, Chien CT (Corresponding author). Sialic acid rescues re-purified lipopolysaccharide-induced acute renal failure via inhibiting TLR4/PKC/gp91-mediated endoplasmic reticulum stress, apoptosis, autophagy, and pyroptosis signaling. Toxicol Sci. 2014 Sep 141(1):155-65.
  40. Chien CY, Chien CT (Corresponding author), Wang SS. Progressive thermopreconditioning attenuates rat cardiac ischemia/reperfusion injury by mitochondria-mediated antioxidant and antiapoptotic mechanisms. J Thorac Cardiovasc Surg. 2014 Aug. J Thorac Cardiovasc Surg. 148(2):705-13. pii: S0022-5223(14)00042-7. doi: 10.1016/j.jtcvs.2013.12.065. [Epub ahead of print]
  41. Yu, C.-J., Ko, C.-J., Hsieh, C.-H., (...), Lee, C.-W., Jiang, C.-C.Document Proteomic analysis of osteoarthritic chondrocyte reveals the hyaluronic acid-regulated proteins involved in chondroprotective effect under oxidative stress
  42. Chien CT, Fan SC, Lin SC, Kuo CC, Yang CH, Yu TY, Lee SP, Cheng DY, Li PC. Glucagon-Like Peptide-1 Receptor Agonist Activation Ameliorates Venous Thrombosis-Induced Arteriovenous Fistula Failure in Chronic Kidney Diseases. 2014 NovThrombosis and Haemostasis 112(5):1051-64.
  43. Yang CC, Chen KH, Hsu SP, Chien CT (Corresponding author). Augmented renal prostacyclin by intrarenal bicistronic cyclo-oxygenase-1/prostacyclin synthase gene transfer attenuates renal ischemia-reperfusion injury. Transplantation. 2013 Dec 27;96(12):1043-51. doi: 10.1097/TP.0b013e3182a77e52.
  44. Tsai, W.-H., Yang, C.-C., Li, P.-C., Chen, W.-C., Chien, C.-T. Document Therapeutic potential of traditional chinese medicine on inflammatory diseases
  45. Yang JC, Yang HC, Shun CT, Wang TH, Chien CT (Corresponding author), Kao JY. Catechins and sialic acid attenuate Helicobacter pylori-triggered epithelial caspase-1 activity and eradicate Helicobacter pylori infection. Evid Based Complement Alternat Med. 2013;2013:248585. doi: 10.1155/2013/248585. Epub 2013 Apr 11.
  46. Li PC, Tsai WH, Chien CT (Corresponding author). Dietary Monascus adlay supplements facilitate suppression of cigarette smoke-induced pulmonary endoplasmic reticulum stress, autophagy, apoptosis and emphysema-related PLGF in the rat. Food Chem. 2013 136(2):765-74.
  47. Hung GD, Li PC, Lee HS, Chang HM, Chien CT (Corresponding author), Lee KL. Green tea extract supplementation ameliorates CCl4-induced hepatic oxidative stress, fibrosis, and acute-phase protein expression in rat. J Formos Med Assoc. 2012 111(10):550-9.
  48. Li PC, Yang CC, Hsu SP, Chien CT (Corresponding author). Repetitive progressive thermal preconditioning hinders thrombosis by reinforcing phosphatidylinositol 3-kinase/Akt-dependent heat-shock protein/endothelial nitric oxide synthase signaling. J Vasc Surg. 2012 Jul;56(1):159-70.
  49. Chang JJ, Lee YH, Wu MH, Yang MC, Chien CT (Corresponding author). Electrospun anti-adhesion barrier made of chitosan alginate for reducing peritoneal adhesions. Carbohydrate Polymers 2012, 88(4): 1304-1312.
  50. Chang JJ, Lee YH, Wu MH, Yang MC, Chien CT (通訊作者). Preparation of electrospun alginate fibers with chitosan sheath. 2012 Carbohydrate Polymers 87:2357-2361.
  51. Chien CT, Lee HM, Wu CC, Li PC. Inhibitory effect of botulinum toxin type A on the NANC system in rat respiratory models of neurogenic inflammation. Arch Biochem Biophys. 2012 524(2):106-13.
  52. Chung SD, Lai TY, Chien CT (Corresponding author), Yu HJ. Activating Nrf-2 signaling depresses unilateral ureteral obstruction-evoked mitochondrial stress-related autophagy, apoptosis and pyroptosis in kidney. PLoS One. 2012;7(10):e47299.
  53. Lee YH, Chang JJ, Yang MC, Chien CT (通訊作者). Lai WF. (corresponding author)Acceleration of wound healing in diabetic rats by layered hydrogel dressing. 2012 Carbohydrate Polymers 88 (3): 809-819.
  54. Yeh CH, Chiang HS, Lai TY, Chien CT (Corresponding author). Unilateral ureteral obstruction evokes renal tubular apoptosis via the enhanced oxidative stress and endoplasmic reticulum stress in the rat. 2011 Mar Neurourol Urodyn. 30(3):472-9.
  55. Chen DL, Chen TW, Chien CT (Corresponding author), Li PC. Intravenous low redox potential saline attenuates FeCl3-induced vascular dysfunction via downregulation of endothelial H2O2, CX3CL1, intercellular adhesion molecule-1, and p53 expression. 2011. Translational Res.157(5):306-19.
  56. Chen KH, Lin BR, Chien CT (Corresponding author), Ho CH. Emblica officinalis Gaertn. attenuates N-nitrosodiethylamine-induced apoptosis, autophagy, and inflammation in rat livers. 2011 Jul-Aug. J Med Food. 14(7-8):746-55.
  57. Chen KH, Li PC, Lin WH, Chien CT (Corresponding author), Low BH. Depression by a green tea extract of alcohol-induced oxidative stress and lipogenesis in rat liver. 2011 Sep 23 Biosci Biotechnol Biochem. 75(9):1668-76.
  58. Wu MF, Li PC, Chen CC, Ye SS, Chien CT, Yu CC. (通訊作者) Cordyceps sobolifera extract ameliorates lipopolysaccharide-induced renal dysfunction in the rat. 2011 Am J Chin Med.;39(3):523-35.
  59. Yeh CH, Chiang HS, Lai TY, Chien CT (通訊作者). Unilateral ureteral obstruction evokes renal tubular apoptosis via the enhanced oxidative stress and endoplasmic reticulum stress in the rat. 2011 Mar Neurourol Urodyn. 30(3):472-9.
  60. Lee WC, Chuang YC, Chiang PH, Chien CT (通訊作者), Yu HJ, Wu CC. Pathophysiological studies of overactive bladder and bladder motor dysfunction in a rat model of metabolic syndrome. 2011 Jul J Urol. 186(1):318-25.
  61. Lee YH, Chang JJ, Lai WF, Yang MC, Chien CT(通訊作者). Layered hydrogel of poly(γ-glutamic acid), sodium alginate, and chitosan: fluorescence observation of structure and cytocompatibility. 2011 Sep Colloids Surf B: Biointerfaces. 1;86(2):409-13.
  62. Hsu SP, Tsai TJ, Chien CT. Ioxitalamate induces renal tubular apoptosis via activation of renal efferent nerve-mediated adrenergic signaling, renin activity and reactive oxygen species production in rats. Toxicol Sci. 2010, 114(1):149-58.
  63. Huang KC, Hsu SP, Yang CC, Ou-Yang P, Lee KT, Morisawa S, Otsubo K, Chien CT(通訊作者). Electrolysed-reduced water dialysate improves T-cell damage in end-stage renal disease patients with chronic haemodialysis. Nephrol Dial Transplant. 2010 Aug;25(8):2730-7.
  64. Yeh CH, Chiang HS, Chien CT. Hyaluronic acid ameliorates bladder hyperactivity via the inhibition of H2O2-enhanced purinergic and muscarinic signaling in the rat.Neurourol Urodyn. 2010 Jun;29(5):765-70.
  65. Hsu SP, Chiang CK, Yang SY, Chien CT (Corresponding author). N-Acetylcysteine for the management of anemia and oxidative stress in hemodialysis patients. Nephron Clin Pract. 2010 Jul 2;116(3):c207-c216.
  66. Yeh CH, Hsu SP, Yang CC, Chien CT (Corresponding author), Wang NP. Hypoxic preconditioning reinforces HIF-alpha-dependent HSP70 signaling to reduce ischemic renal failure-induced renal tubular apoptosis and autophagy. Life Sci. 2010 Jan 16;86(3-4):115-23.
  67. Yang CH, Lin CY, Yang JH, Liou SY, Li PC, Chien CT (Corresponding author). Supplementary catechins attenuate cooking-oil-fumes-induced oxidative stress in rat lung. Chin J Physiol. 2009 Jun 30;52(3):151-9.
  68. Huang SC, Tsai YF, Cheng YS, Liu KH, Li PC, Chien CT(通訊作者). Vascular protection with less activation evoked by progressive thermal preconditioning in adrenergic receptor-mediated hypertension and tachycardia. Chin J Physiol. 2009 Dec 31;52(6):419-25.
  69. Chen SS, Chen WC, Hayakawa S, Li PC, Chien CT (Corresponding author). Acute urinary bladder distension triggers ICAM-1-mediated renal oxidative injury via the norepinephrine-renin-angiotensin II system in rats. J Formos Med Assoc. 2009 Aug;108(8):627-35.
  70. Yang JC, Chien CT (Corresponding author). A new approach for the prevention and treatment of Helicobacter pylori infection via upregulation of autophagy and downregulation of apoptosis. Autophagy. 2009 Apr;5(3):413-4. Epub 2009 Apr 13.
  71. Ho CH, Hsu SP, Yang CC, Lee YH, Chien CT (Corresponding author). Sialic acid reduces acute endotoxemia-induced liver dysfunction in the rat. Shock. 2009 Aug;32(2):228-35.
  72. Lin BR, Yu CJ, Chen WC, Lee HS, Chang HM, Lee YC, Chien CT(通訊作者), Chen CF. Green tea extract supplement reduces D-galactosamine-induced acute liver injury by inhibition of apoptotic and proinflammatory signaling. J Biomed Sci. 2009 Mar 25;16:35.
  73. Yen YH, Chen WC, Hayakawa S, Chien CT(通訊作者). In-chern-hau-tang and genipin reduces acute urinary bladder distension evoked sympathetic activation-induced hepatic dysfunction in rats. Am J Chin Med. 2009;37(2):339-49.
  74. Wu HH, Hsiao TY, Chien CT(通訊作者), Lai MK. Ischemic conditioning by short periods of reperfusion attenuates renal ischemia/reperfusion induced apoptosis and autophagy in the rat. J Biomed Sci. 2009 Feb 11;16:19.
  75. Kuo DC, Hsu SP, Chien CT(通訊作者). Partially hydrolyzed guar gum supplement reduces high-fat diet increased blood lipids and oxidative stress and ameliorates FeCl3-induced acute arterial injury in hamsters. J Biomed Sci. 2009 Feb 2;16:15.
  76. Yang CC, Lin LC, Wu MS, Chien CT (Corresponding author), Lai MK. Repetitive hypoxic preconditioning attenuates renal ischemia/reperfusion induced oxidative injury via upregulating HIF-1 alpha-dependent bcl-2 signaling. Transplantation. 2009 Dec 15;88(11):1251-60.
  77. Lee FT, Kuo TY, Liou SY, Chien CT(通訊作者). Chronic Rhodiola rosea extract supplementation enforces exhaustive swimming tolerance. Am J Chin Med. 2009;37(3):557-72.

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